More articles from Research Articles
d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen speciesThis study reveals a novel role of d-amino acid oxidase in promoting cellular senescence induced by genotoxic stresses via enzymatic generation of reactive oxygen species.
Rab1b and ARF5 are novel RNA-binding proteins involved in FMDV IRES–driven RNA localizationIntegration of proteomic data with functional and imaging analysis revealed that Rab1b and ARF5, two ER-Golgi members, are RNA-binding proteins that colocalize with picornavirus IRES-RNA reporters in human cells.
KIF18A's neck linker permits navigation of microtubule-bound obstacles within the mitotic spindleThe length of KIF18A's neck linker permits navigation of obstacles along K-fibers within the mitotic spindle and is required for the timely alignment and segregation of mitotic chromosomes.
A junction coverage compatibility score to quantify the reliability of transcript abundance estimates and annotation catalogsComparison of observed exon–exon junction counts to those predicted from estimated transcript abundances can identify genes with misannotated or misquantified transcripts.
Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoesExpression patterns of transcripts in reproductive tissues reveal the phylogeny of the An. gambiae complex and are indicative of molecular function, transcription regulatory networks, and protein–protein interaction networks.
Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPaseNovel GAK phosphorylation targets are identified using chemical genetic methods. One of the substrates is the α subunit of the Na+/K+-ATPase, phosphorylation of which is necessary for its surface trafficking from endosomes. Conserved functions of NAK family kinases are described.
Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1The C-terminal end of Cdt2 contains a PIP box for binding to PCNA to promote CRL4Cdt2 function, creating a new paradigm where the substrate receptor and substrates bind to a common multivalent docking platform for ubiquitination.
Mechanistic aspects of maltotriose-conjugate translocation to the Gram-negative bacteria cytoplasmA maltotriose-conjugate can deliver molecules into the cytoplasmic space of Gram-negative bacteria by parasitizing the maltose uptake pathway.
Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycleCaenorhabditis elegans lineage is invariant between animals. By challenging cell fate in differentiated worms, an unexpected role of Polycomb and Notch signaling in the control of cell proliferation was uncovered, suggesting that the lineage is more flexible than believed.
A C/EBPα–Wnt connection in gut homeostasis and carcinogenesisThis research reveals an antagonism between C/EBPα expression and activated Wnt signaling in the human and mouse gut and suggests a tumor suppressor function of C/EBPα in human and murine intestinal cancer.