More articles from Research Articles
Centrosome guides spatial activation of Rac to control cell polarization and directed cell migrationThe centrosome acts as a controller by balancing the formation of centrosomal and acentrosomal microtubules, the modulation of focal adhesion signaling and the activation of local Rac1 at the cell front, which then coordinates cell polarization during directed cell migration.
DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophagesThis study shows that caspase-1 autocleavage, ASC speck assembly, and mature IL-1β and IL-18 secretion accompany rapid DPP8/DPP9-regulated pyroptosis induction in macrophages expressing a LeTx-responsive Nlrp1b allele.
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund–Thomson syndromeRECQL4, which is mutated in the Rothmund–Thomson syndrome characterized by premature aging and cancer susceptibility, is a microtubule-associated protein required for mitotic chromosome alignment.
Somatic recombination underlies frequent revertant mosaicism in loricrin keratodermaWe demonstrate that revertant mosaicism frequently occurs in loricrin keratoderma and that somatic recombination is the major mechanism underlying this therapeutically important phenomenon.
Redundant and nonredundant organismal functions of EPS15 and EPS15L1This study unveils a redundant function for the endocytic proteins Eps15 and Eps15L1 in mouse embryo development and erythropoiesis, and a unique nonredundant role for Eps15L1 in the nervous system.
Mitochondrial stress response triggered by defects in protein synthesis quality controlQuality control defects of mitochondrial nascent chain synthesis trigger a sequential stress response characterized by OMA1 activation and ribosome decay, determining mitochondrial form and function.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and functionCostimulation of T cells through both TCR and STING induces growth inhibition by partially blocking the mTORC1 signals, and leads to IFN-I production through sustained activation of IRF3 and mTORC1 activation.
Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogasterDepletion of miRNA-210 disrupts photoreceptor integrity and visual function in Drosophila melanogaster.
Viperin controls chikungunya virus–specific pathogenic T cell IFNγ Th1 stimulation in miceThis study shows that Viperin controls the microenvironment pro-inflammatory response and CD4 T cell–mediated pathogenesis during anti-chikungunya virus immune response in mice.
Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutantsThe tight correlation between folding and function in cystic fibrosis patients with CFTR mutations of the altered-conductance CFTR class provides an attractive paradigm for characterizing mode of action of novel therapeutics.