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Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signallingHuman but not yeast UBA1 binds poly(ADP-ribose) polymers via a solvent-exposed and positively charged patch. Poly(ADP-ribose) polymerase 1–dependent recruitment of UBA1 to DNA ensures ataxia-telangiectasia and RAD3-related activation.
Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in gliomaUsing phospho-proteomics in a new model of malignant glioma, we reveal that clinically relevant, chronic PDGFRα signaling differs considerably from acute receptor stimulation and unveils previously unrecognized control over key elements of the translation initiation machinery.
DHX15 regulates CMTR1-dependent gene expression and cell proliferationDHX15 helicase regulates CMTR1-dependent first transcribed nucleotide ribose O-2 methylation.
Co-existing feedback loops generate tissue-specific circadian rhythmsThe analysis of tissue-specific data-based models of the gene regulatory network of the mammalian circadian clock reveals organ-specific synergies of feedback loops.
Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapsesSuper-resolution microscopy reveals that Aβ42 is mainly present at the presynaptic side of the synapse.
Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1The stepwise ribosome disassembly in the translation cycle of eukaryotes and archaea is scheduled by discrete molecular events within the asymmetric ribosome recycling factor ABCE1.
Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cellsDepletion of FACT in murine embryonic stem cells show mild changes on the nucleosomal landscape but widespread changes in the transcriptome, faster proliferation, and neuronal differentiation rates.
ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1CREB1 interacts with, stimulates, and is necessary for estrogen receptor α activation by estrogen or cAMP signaling, and this cooperation may underlie their anti-apoptotic activities in breast cancer cells.
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhAAN12855 is a novel cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. AN12855 has potent activity against M. tuberculosis, good oral bioavailability, and comparable efficacy to isoniazid in infection models.
The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunityArabidopsis homolog of human G3BP1 negatively regulates plant immunity and defense responses. Atg3bp1 mutant lines show constitutive stomata closure, expression of a number of key defense marker genes, and accumulate salicylic acid.