More articles from Research Articles
Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defenseIrgb6 has a role in the cell-autonomous response against T. gondii and involves ubiquitination and breakdown of vacuoles via binding of a specific phospholipid on the parasitophorous vacuole membrane.
aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion modelTransient activation of YAP with a modified mRNA after ischemia-reperfusion stress reduces cardiac inflammation, attenuates cardiac hypertrophic remodeling and helps to salvage the myocardium.
Metabolome-based prediction of yield heterosis contributes to the breeding of elite riceMetabolite profiles obtained from parental seedlings can predict yield heterosis of rice hybrids with correctly dissected population structure across different growth conditions.
Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domainComparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.
Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosisImmune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.
MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sitesMERLIN is a novel biosensor that generates a BRET signal with a signal-to-noise ratio that is sufficient to enable sensing the proximity between the mitochondria and the ER without forcing interaction or establishing artificial connections at the MERCs.
Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cellsLoss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103+CD11b+ cDC2s, which was accompanied with impaired differentiation of both Rorγt+ Th17 cells and type 3 Rorγt+ Treg cells.
TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-lifeThis study demonstrates that the tetraspanins Tspan5 and Tspan15 which directly associate with the metalloprotease ADAM10 have an opposite impact on its endocytosis and half-life.
Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compoundsThis study provides comprehensive insights into the mechanism of action and cellular effects of circadian period–modulating compounds, which is critical for clearly defining molecular targets to modulate daily rhythms for therapeutic benefit.
CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulationIKKα is an NSCLC suppressor and its loss in mouse AT-II lung epithelial cells or in human NSCLC lines increased urethane-induced adenoma growth and xenograft burdens, respectively. IKKα loss can up-regulate HIF-1α, enhancing tumor growth under hypoxia.