More articles from Research Articles
- Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation
Deletion of genes encoding vertebrate clathrin light chain isoforms reveals a role for both in epithelial lumen formation and dominance of CLCa function in vivo during uterine epithelium development.
- Evolutionary insights into 3D genome organization and epigenetic landscape of Vigna mungo
By integrating SMRT long read, Hi-C, and Illumina pair-end sequencing technologies, we report a nearly complete, chromosomal-level assembly of V. mungo and characterize its 3D genome architecture.
- Characterization of Na+ currents regulating intrinsic excitability of optic tectal neurons
This study examines how developing optic tectal neurons adapt their intrinsic excitability. Changes in Nav 1.1 and 1.6 expressions correlate with changes in intrinsic excitability, whereas dynamic regulation of Nav1.6 is central for intrinsic plasticity and normal sensory circuit development.
- Suppressed transcript diversity and immune response in COVID-19 ICU patients: a longitudinal study
This integrative longitudinal clinico-genomic study delves deep into the gene and transcript expression pattern dynamics in severe COVID-19 patients with ARDS admitted to the ICU.
- Meta-analysis of dispensable essential genes and their interactions with bypass suppressors
This work compiles data from several studies on dispensable essential genes in S. cerevisiae to comprehensively characterize these genes and to explore how their interactions with bypass suppressor genes reflect evolution in natural populations.
- Polycomb regulates circadian rhythms in Drosophila in clock neurons
This study demonstrated that Pc regulates the circadian rhythm. The targeted DamID analysis identified the Pc-binding profiles in different clock neuron clusters, indicating Pc regulates circadian rhythms by specific clock genes.
- Cell cycle-dependent gene networks for cell proliferation activated by nuclear CK2α complexes
Functional connection between activation of nuclear CK2α by phosphorylation which leads to association of CK2α with transcriptional start sites, and activation of histone genes, growth-related genes, and rDNA for cell proliferation.
- Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation
Simultaneous deficiency of three tristetraprolin family members in myeloid cells resulted in severe inflammation in mice, suggesting that these three proteins act together to prevent inflammation.
- Biogenesis, inheritance, and 3D ultrastructure of the microsporidian mitosome
Quantitative electron and light microscopy combined with bioinformatics reveal that microsporidian mitosomes grow and divide incrementally and are inherited at the microsporidian centrosome (spindle pole body), whereas mitochondrial dynamins participate in mitosome division.
- APR-246 increases tumor antigenicity independent of p53
Michels, Venkatesh et al demonstrate that APR-246, a small molecule Michael acceptor, enhances tumor immunogenicity. Combination of APR-246 with immune modulation enhances antitumor responses. APR-246, initially described as a P53 stabilizer, induces immunogenicity irrespective of the tumor’s p53 status.