More articles from Research Articles
Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cellsConstitutive CD8 expression induces differentiation of innate memory-like CD8+ thymocytes in both cell-intrinsic and cell-extrinsic manner, the latter being accomplished by an increase in the iNKT2 subset.
Virus-induced transposable element expression up-regulation in human and mouse host cellsGenome-wide transposon expression up-regulation in host cells regardless of virus, species, and host cell tissue types occurs early during viral infection and likely contributes to promoting the host innate immune response.
Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodelingThis study highlights the role of Nup93-chromatin interactions in driving triple-negative breast cancer propagation through modulation of the actin cytoskeleton, cell migration and proliferation.
Laminin is the ECM niche for trophoblast stem cellsLaminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin.
TRAP1 chaperone protein mutations and autoinflammationThis study identifies patients with autoinflammation and mutations affecting the mitochondrial/ER protein chaperone TRAP1, either alone or digenic, with MEFV mutation possibly synergizing to produce severe disease. TRAP1 mutations lead to increased mitochondrial reactive oxygen species and may contribute to autoinflammation.
Oscillatory cAMP signaling rapidly alters H3K4 methylationThis work explores how GPCR-cAMP signaling dynamically influences histone methylation by altering intracellular labile Fe(II) levels and subsequently modulating histone demethylase activity.
CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesisCLIC members are required for the progression of cytokinesis by coupling the plasma membrane and cortical actin network at the cleavage furrow and polar cortex.
Loss of autophagy impairs physiological steatosis by accumulation of NCoR1Autophagy regulates fatty acid and triglyceride synthesis at the transcriptional level by fine-tuning the levels of NCoR1, a negative regulator of nuclear receptors. Defective autophagy impairs physiological steatosis both under fasting conditions and after hepatectomy.
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virusAn expanded hydrophobic cavity within the structurally constrained receptor-binding site of the Cedar virus attachment glycoprotein facilitates idiosyncratic utilization of ephrin-B1.
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylationMitochondrial fusion requires a conformational change in α4 of the GTPase domain, followed by AAA-ATPase regulation, thus revealing striking mechanistic similarities between small and large GTPases.