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The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylationThe CCR4–NOT complex maintains liver homeostasis by fine-tuning levels of mRNAs, including those for transcription factors, cell cycle regulators, DNA damage response proteins, and liver function–related molecules.
Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicinA pseudomonad isolated from garlic has multiple copies of genes on three genomic islands that confer resistance to allicin, a secondary plant product and defense substance that causes disulfide stress.
CDKL3 promotes osteosarcoma progression by activating Akt/PKBThis study demonstrates that CDKL3 regulates Akt activation and its downstream targets to promote OS progression, creating a therapeutically targetable vulnerability in treatment of OS.
Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do notGenetic differences between C57BL/6 substrains lead to different cardiovascular traits; a null mutation in Mylk3 likely causes cardiomyopathy in C57BL/6N mice, whereas C57BL/6J Nnt-null mice do not develop cardiomyopathy.
A novel class of polymorphic toxins in BacteroidetesBacteria often use toxins to mediate their interaction with the environment. This study reveals a new class of polymorphic toxins, which contain an N-terminal TANFOR domain, in Bacteroidetes.
CSDE1 controls gene expression through the miRNA-mediated decay machineryCSDE1 is a new component of miRNA-induced silencing complex and interacts with DCP1–DCP2 decapping machinery with potential roles in miRNA-mediated target degradation.
BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expressionOur work highlights BACH family of transcription factors as a novel regulator of angiogenesis and lymphangiogenesis during zebrafish embryonic development and tumor expansion.
Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR foldThe structures of SALSA SRCR domains 1 and 8 reveal a cation-dependent mechanism for ligand recognition, contributing to important roles in the immune system and cellular signalling. The cation-binding sites are conserved across all SRCR domains, suggesting conserved functional mechanisms.
Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in miceIL-36 stimulation of keratinocytes orchestrates key pathogenic inflammatory responses in psoriatic skin.
Splicing of enhancer-associated lincRNAs contributes to enhancer activityAnalysis of enhancer-associated lincRNA transcripts shows their efficient and conserved splicing contributes to cognate enhancer activity and cis-regulation of target gene expression.