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Exploiting somatic piRNAs in Bemisia tabaci enables novel gene silencing through RNA feedingRNAi usually relies on Dicer-produced siRNAs to induce gene silencing. In many arthropods, another type of RNAi is present in the soma—the piRNA pathway. This work finds exploiting this biology is a viable alternative for gene knockdown.
Peptide-based quorum sensing systems in Paenibacillus polymyxaDiscovery of conserved communication systems in the agriculturally important Paenibacillus bacteria. These systems are widespread, and some species encode more than 25 different peptide-receptor pairs.
Sam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscleSam68 ensures the establishment of neuromuscular junctions (NMJs) and motor unit integrity by orchestrating a neuronal splicing program.
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortalityAffinity-based proteomics assays identify particular profiles of the circulating histidine-rich glycoprotein to increase with age and elevated levels to indicate a higher risk of all-cause mortality.
Mitochondrial spongiotic brain disease: astrocytic stress and harmful rapamycin and ketosis effectAstrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. Astrocytes, but not neurons, drive mitochondrial integrated stress response in the CNS.
A time-resolved interaction analysis of Bem1 reconstructs the flow of Cdc42 during polar growthA temporal dissection correlates changes in composition and architecture of the interaction network of Bem1 with changes in cellular morphology and the activities of its binding partners.
CYP20-3 deglutathionylates 2-CysPRX A and suppresses peroxide detoxification during heat stressPosttranslational modification by a reduced glutathione determines distinctive quaternary structures and functions between two 2-cysteine peroxiredoxin A and B in the chloroplasts.
CryoEM structure of Drosophila flight muscle thick filaments at 7 Å resolutionRelaxed thick filaments from Drosophila flight muscle show disordered myosin heads, a ribbon arrangement of myosin tails and a novel protein, stretchin-klp, on the filament surface.
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to LegionellaThe analysis of the relationships between different deubiquitinase classes leads to the definition of an aromatic “gatekeeper” motif that distinguishes DUBs from other cysteine proteases and helps to predict new bacterial DUBs.
Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cellsPD-1high memory CD4 T cells are pathogenic in autoimmune disease; here they show their expression of Egr2 is defective in rheumatoid arthritis and Egr2 & 3 control their inflammation and homeostasis.