More articles from Research Articles
- The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer
Using patient-derived organoids the authors show how a specialized polarity pathway protects our gut barrier from stress-induced collapse. Findings highlight both diagnostic and therapeutic potential of the pathway for treating gut barrier dysfunction in aging, cancer, and dysbiosis.
- Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis
This study presents evidence that CRK/CRKL and TBX1 may share pathways that participate in organogenesis affected in DiGeorge syndrome (22q11.2DS) via global control of gene expression and metabolism
- ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue
The endoplasmic reticulum-resident sensor PERK is phosphorylated during brown adipocyte differentiation and is required for mitochondrial inner membrane protein biogenesis and thermogenic function.
- Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire
Germinal center B cells infected with gammaherpesvirus display altered repertoire with biased usage of lambda light chain and skewed utilization of IGHV genes.
- Site-specific phosphorylation regulates the functions of kindlin-3 in a variety of cells
A new monoclonal antibody in combination with mutational analyses shows that a single serine phosphorylation in kindlin-3 is functionally important in both hematopoietic and non-hematopoietic cells.
- Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration
High-fat diet ameliorates muscle dystrophic phenotype by promoting the FAP-dependent myogenesis of satellite cells.
- Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells
Intracellular trafficking of Argonaute 2 controls de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells.
- Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO
Oxidised omega-6 fatty acids activate the FOXO transducers of the Insulin signaling pathway potentially linking changes in dietary fatty acid balance and proinflammatory states with insulin resistance.
- Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
Chromosomal instability (CIN) is a hallmark feature of cancer cells. In this study, Schukken and colleagues screen for compounds that selectively target CIN cells and identify an inhibitor of Src kinase to be selectively toxic for CIN cells.
- Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells
Constitutive CD8 expression induces differentiation of innate memory-like CD8+ thymocytes in both cell-intrinsic and cell-extrinsic manner, the latter being accomplished by an increase in the iNKT2 subset.