More articles from Research Articles
- SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis
During meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCFCdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly.
- Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies
We found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges. Unlike draining CNS-cervical lymph nodes, meningeal lymphocytes are locally activated during neuro-inflammtion and neurodegeneration.
- Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
Autocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation.
- Scratch-induced partial skin wounds re-epithelialize by sheets of independently migrating keratinocytes
Intravital microscopy of scratch wounds in the murine skin reveals that individual basal keratinocytes migrate in a swarming fashion towards the wound to bypass intact hair follicles, thereby facilitating fast repair.
- G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation
Granulocyte colony-stimulating factor suppresses erythropoiesis of bone marrow and promotes splenic erythropoiesis during lipopolysaccharide-induced systemic inflammation in mice.
- Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy
We describe drug treatment paradigms that allow investigation of cellular and molecular pathogenesis at different stages of spinal muscular atrophy in a mouse model.
- Inhibiting the reproduction of SARS-CoV-2 through perturbations in human lung cell metabolic network
Using genomic and structural information from SARS-CoV-2, we created a biomass function capturing its amino and nucleic acid requirements and incorporated this into a metabolic model of the human lung cell to predict metabolic perturbations that inhibit virus reproduction.
- BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
Upon cholesterol deprivation, epigenetic bookmark reader BRD2 and master transcription factor SREBP2 form a complex at bookmarked chromatin (H3K27ac), thereby activating the transcription of the sigma-2 receptor—a recently unveiled player in cholesterol homeostasis.
- Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers
WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors.
- Characterization of ori and parS-like functions in secondary genome replicons in Deinococcus radiodurans
An array of direct repeats upstream to parAB operon helps in secondary genome elements’ maintenance independent of primary chromosome in multipartite genome harboring bacterium Deinococcus radiodurans.