More articles from Research Articles
Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasisA renal CD169++ resident macrophage subpopulation controls Candida albicans growth, severe kidney inflammation, and immunopathology during acute systemic candidiasis.
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification programThis work shows that GATA transcription factors transduce the BMP signaling and, with SOX17 and TFAP2C, induce the human germ-cell fate, delineating the mechanism for human germ-cell specification.
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen responseThis work shows that activation of the main cellular stress response pathway is responsible for antiestrogen resistance in breast cancer, a process that is reversible.
A systems-based method to repurpose marketed therapeutics for antiviral use: a SARS-CoV-2 case studyThis study describes complementary network-based and sequence similarity methods to identify drug repurposing opportunities predicted to directly target viral proteins, highlighting results for five human pathogens.
Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switchNK cell reactivity is dynamically regulated by IL-15, and NK cells do not need more than a few minutes of exposure to remember the cytokine for several hours.
A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8This study uncovers a critical role of DOCK8 in coupling PI(4,5)P2 signaling with Cdc42 activation through its DHR-1 domain during interstitial leukocyte migration.
SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamstersUsing an aged Syrian hamster model, which develops severe morbidity upon SARS-CoV-2 infection including death, we demonstrated that the immunity induced by a natural infection not only protects hamsters from reinfection but also significantly limits transmission via close contact.
CDCP1 promotes compensatory renal growth by integrating Src and Met signalingCDCP1 promotes HGF-induced compensatory renal growth by focally and temporally integrating Src and Met-STAT3 signaling in lipid rafts.
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferaseCryo-EM structures of the human SET8–nucleosome complexes reveal the mechanism by which the SET8 methyltransferase binds the nucleosome and specifically recognizes the histone H4 lysine-20 residue.
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotectionThe neuroprotective effects of the cold-shock protein RBM3 have broad appeal for therapy. RBM3 induction through cooling occurs through a non-canonical pattern of TrkB signaling. The pathway can now be targeted pharmacologically for RBM3-mediated neuroprotection without the need for cooling.