More articles from Research Articles
SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamstersUsing an aged Syrian hamster model, which develops severe morbidity upon SARS-CoV-2 infection including death, we demonstrated that the immunity induced by a natural infection not only protects hamsters from reinfection but also significantly limits transmission via close contact.
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferaseCryo-EM structures of the human SET8–nucleosome complexes reveal the mechanism by which the SET8 methyltransferase binds the nucleosome and specifically recognizes the histone H4 lysine-20 residue.
CDCP1 promotes compensatory renal growth by integrating Src and Met signalingCDCP1 promotes HGF-induced compensatory renal growth by focally and temporally integrating Src and Met-STAT3 signaling in lipid rafts.
TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotectionThe neuroprotective effects of the cold-shock protein RBM3 have broad appeal for therapy. RBM3 induction through cooling occurs through a non-canonical pattern of TrkB signaling. The pathway can now be targeted pharmacologically for RBM3-mediated neuroprotection without the need for cooling.
1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cellsAlcohol, 1,6-hexanediol, is widely used for melting liquid droplets formed by liquid0–liquid phase separation; however, it can also seriously affect cells by immobilizing and condensing chromatin.
Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic controlThorough preclinical evaluation reveals a negligible role of lipocalin 13 in systemic glucose and lipid metabolism.
Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter familyA new structure of GLUT1, compared with GLUT3, can explain substrate affinity differences, and provide a functional rationale for key structural motifs that define the universal Sugar Porter family.
Insulin signaling mediates neurodegeneration in gliomaTumoral cells secrete an antagonist that attenuates insulin signaling in neurons. It induces mitochondrial defects and synapse loss; restoring neuronal insulin activity rescues neurodegeneration.
Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosisXie et al demonstrate opposite outcomes on liver fibrosis due to deletion of c-Jun in hepatocytes alone or along with Kupffer cells, highlighting the functional interaction between these cell types in regulating the fibrotic process, dictated by c-Jun.
A novel role of DNA polymerase λ in translesion synthesis in conjunction with DNA polymerase ζAs an integral scaffolding component of DNA polymerase (Pol) zeta, Pol lambda adapts Pol zeta–dependent translesion synthesis to operate in a predominantly error-free manner in human cells.