More articles from Research Articles
- Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation
This work reveals that megakaryocytes transfer cGAS and STING proteins to platelets during thrombopoiesis and that cGAS stimulation results in the activation and aggregation of platelets, suggesting a new role of cGAS in thromboinflammation.
- Decline of DNA damage response along with myogenic differentiation
In postmitotic myotubes, DNA repair processes such as Base Excision Repair, and Non-Homologous End Joining are weakened compared with the proliferative precursors myoblasts.
- Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification
This study shows that signalling processes prime many enhancer elements at the chromatin level before the expression of their associated genes and that priming is essential for developmental stage-specific dynamic gene activation.
- Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells
The study shows that estrogen activates transcription within pre-established chromosomal 3D architectures, strengthening enhancer interactions through local accumulation of the estrogen receptor α.
- Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles
The unintended 10q23.31 deletion frequency rises in HAP1 cells stressed during CRISPR-Cas9 engineering, leading to aberrant molecular and cellular changes resembling common cancer patient deletions.
- Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure
We exposed pregnant female mice to neonicotinoid thiacloprid. We observed reproductive defects together with DNA methylation and histone H3K9me3 changes in the third-generation males.
- DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway
This study reveals that decreased DOCK1 in placental villi affects trophoblast function via the DUSP4-ERK pathway, providing insights into adverse pregnancy outcomes.
- Cristae dynamics is modulated in bioenergetically compromised mitochondria
Live-cell super-resolution nanoscopy reveals modulation of cristae dynamics in bioenergetically compromised mitochondria demonstrating that cristae morphology and dynamics are intricately connected.
- Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3
The study shows that Yap1 expression correlates with poor outcomes in human gastric cancer and causally contributes to disease progression in mice via cancer cell–intrinsic and –extrinsic mechanisms.
- Visualization of conformational transition of GRP94 in solution
SAXS, nsEM, and HDX-MS reveal that one extended and two compact conformations of GRP94 coexist in solution and that the binding and hydrolysis of ATP only drives the transition between the two compact conformations while leaving the extended population unaffected.