More articles from Research Articles
Analysis of context-specific KRAS–effector (sub)complexes in Caco-2 cellsWe used affinity purification of KRAS in different genetic and growth contexts to determine KRAS-mediated complexes, their rewiring in specific contexts, and their link to functional outcomes.
Preference of CAMSAP3 for expanded microtubule lattice contributes to stabilization of the minus endD2 region in CAMSAP3 preferentially bound to expanded microtubule lattices and also induced lattice expansion, explaining the molecular functions of CAMSAP3.
The TUDOR domain of SMN is an H3K79me1 histone mark readerThe survival of motor neuron (SMN) protein is depleted in spinal muscular atrophy (SMA) pathology and herein defined as the first reader of histone H3 mono-methylated on lysine 79 through its central TUDOR domain.
Defibrotide impact on the acute GVHD disease incidence in pediatric hematopoietic stem cell transplant recipientsThe prophylactic use of defibrotide in pediatric HSCT recipients significantly reduces the incidence and severity of acute GVHD, with a modification of cytokine pattern, both strongly coherent with the protective drug’s action.
A multiplexed siRNA screen identifies key kinase signaling networks of brain gliaThis study reports a multiplexed brain glial kinase screen, providing insight into the largely unknown glial intracellular signaling networks controlling neuroinflammation and highlights the therapeutic potential of targeting glial kinases to modulate glial phenotypes and treat neuroinflammatory disorders.
Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapiesPatient-derived tumor models show promise for evaluating novel cancer treatments that could improve outcomes for African children diagnosed with EBV-associated endemic Burkitt lymphoma.
RAS and PP2A activities converge on epigenetic gene regulationThis study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.
Regulatory de novo mutations underlying intellectual disabilityThis study provides suggestive evidence that the de novo mutations in fetal brain-specific enhancers play role in the aetiology of intellectual disability.
Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibilityDisruption of SAM domain–mediated polymerization of Polycomb Group protein polyhomeotic decreases nucleosome occupancy in Drosophila S2 cells.
Assessing the impacts of various factors on circular RNA reliabilityThis study systematically assesses the impacts of numerous factors related to circRNA identification, conservation, biogenesis, and function on circRNA reliability, providing a useful guideline and an important resource for selecting high-confidence circRNAs for further investigations.