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More articles from Research Articles

  • Analysis of context-specific KRAS–effector (sub)complexes in Caco-2 cells
    Open Access
    Analysis of context-specific KRAS–effector (sub)complexes in Caco-2 cells

    Camille Ternet, Philipp Junk, Thomas Sevrin, Simona Catozzi, Erik Wåhlén, Johan Heldin, Giorgio Oliviero, Kieran Wynne, Christina Kiel

    Camille Ternet ... Christina Kiel

    Published 9 March 2023

    We used affinity purification of KRAS in different genetic and growth contexts to determine KRAS-mediated complexes, their rewiring in specific contexts, and their link to functional outcomes.

  • Preference of CAMSAP3 for expanded microtubule lattice contributes to stabilization of the minus end
    Open Access
    Preference of CAMSAP3 for expanded microtubule lattice contributes to stabilization of the minus end

    Hanjin Liu, Tomohiro Shima

    Hanjin Liu ... Tomohiro Shima

    Published 9 March 2023

    D2 region in CAMSAP3 preferentially bound to expanded microtubule lattices and also induced lattice expansion, explaining the molecular functions of CAMSAP3.

  • The TUDOR domain of SMN is an H3K79<sup>me1</sup> histone mark reader
    Open Access
    The TUDOR domain of SMN is an H3K79me1 histone mark reader

    Olivier Binda, Aimé Boris Kimenyi Ishimwe, Maxime Galloy, Karine Jacquet, Armelle Corpet, Amélie Fradet-Turcotte, Jocelyn Côté, Patrick Lomonte

    Olivier Binda ... Patrick Lomonte

    Published 7 March 2023

    The survival of motor neuron (SMN) protein is depleted in spinal muscular atrophy (SMA) pathology and herein defined as the first reader of histone H3 mono-methylated on lysine 79 through its central TUDOR domain.

  • Defibrotide impact on the acute GVHD disease incidence in pediatric hematopoietic stem cell transplant recipients
    Open Access
    Defibrotide impact on the acute GVHD disease incidence in pediatric hematopoietic stem cell transplant recipients

    Domenica Squillaci, Annalisa Marcuzzi, Erika Rimondi, Guglielmo Riccio, Egidio Barbi, Davide Zanon, Natalia Maximova

    Domenica Squillaci ... Natalia Maximova

    Published 6 March 2023

    The prophylactic use of defibrotide in pediatric HSCT recipients significantly reduces the incidence and severity of acute GVHD, with a modification of cytokine pattern, both strongly coherent with the protective drug’s action.

  • A multiplexed siRNA screen identifies key kinase signaling networks of brain glia
    Open Access
    A multiplexed siRNA screen identifies key kinase signaling networks of brain glia

    Jong-Heon Kim, Jin Han, Ruqayya Afridi, Jae-Hong Kim, Md Habibur Rahman, Dong Ho Park, Won Suk Lee, Gyun Jee Song, Kyoungho Suk

    Jong-Heon Kim ... Kyoungho Suk

    Published 6 March 2023

    This study reports a multiplexed brain glial kinase screen, providing insight into the largely unknown glial intracellular signaling networks controlling neuroinflammation and highlights the therapeutic potential of targeting glial kinases to modulate glial phenotypes and treat neuroinflammatory disorders.

  • Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
    Open Access
    Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies

    Priya Saikumar Lakshmi, Cliff I Oduor, Catherine S Forconi, Viriato M’Bana, Courtney Bly, Rachel M Gerstein, Juliana A Otieno, John M Ong’echa, Christian Münz, Micah A Luftig, Michael A Brehm, Jeffrey A Bailey, Ann M Moormann

    Priya Saikumar Lakshmi ... Ann M Moormann

    Published 6 March 2023

    Patient-derived tumor models show promise for evaluating novel cancer treatments that could improve outcomes for African children diagnosed with EBV-associated endemic Burkitt lymphoma.

  • RAS and PP2A activities converge on epigenetic gene regulation
    Open Access
    RAS and PP2A activities converge on epigenetic gene regulation

    Anna Aakula, Mukund Sharma, Francesco Tabaro, Reetta Nätkin, Jesse Kamila, Henrik Honkanen, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka Westermarck

    Anna Aakula ... Jukka Westermarck

    Published 1 March 2023

    This study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.

  • Regulatory de novo mutations underlying intellectual disability
    Open Access
    Regulatory de novo mutations underlying intellectual disability

    Matias G De Vas, Fanny Boulet, Shweta S Joshi, Myles G Garstang, Tahir N Khan, Goutham Atla, David Parry, David Moore, Inês Cebola, Shuchen Zhang, Wei Cui, Anne K Lampe, Wayne W Lam, Genomics England Research Consortium, Jorge Ferrer, Madapura M Pradeepa, Santosh S Atanur

    Matias G De Vas ... Santosh S Atanur

    Published 28 February 2023

    This study provides suggestive evidence that the de novo mutations in fetal brain-specific enhancers play role in the aetiology of intellectual disability.

  • Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility
    Open Access
    Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility

    Adfar Amin, Sangram Kadam, Jakub Mieczkowski, Ikhlak Ahmed, Younus A Bhat, Fouziya Shah, Michael Y Tolstorukov, Robert E Kingston, Ranjith Padinhateeri, Ajazul H Wani

    Adfar Amin ... Ajazul H Wani

    Published 27 February 2023

    Disruption of SAM domain–mediated polymerization of Polycomb Group protein polyhomeotic decreases nucleosome occupancy in Drosophila S2 cells.

  • Assessing the impacts of various factors on circular RNA reliability
    Open Access
    Assessing the impacts of various factors on circular RNA reliability

    Trees-Juen Chuang, Tai-Wei Chiang, Chia-Ying Chen

    Trees-Juen Chuang ... Chia-Ying Chen

    Published 27 February 2023

    This study systematically assesses the impacts of numerous factors related to circRNA identification, conservation, biogenesis, and function on circRNA reliability, providing a useful guideline and an important resource for selecting high-confidence circRNAs for further investigations.

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