More articles from Research Articles
RFWD3 and translesion DNA polymerases contribute to PCNA modification–dependent DNA damage toleranceRFWD3 and the translesion DNA polymerases Polκ and Polη, for illudin S and UV DNA lesions, respectively, contribute to PCNA ubiquitination–dependent DNA damage tolerance in human cells.
Drosophila insulator proteins exhibit in vivo liquid–liquid phase separation propertiesDrosophila insulator proteins and the cohesin subunit Rad21 coalesce in vivo to form liquid-droplet condensates, suggesting that liquid–liquid phase separation mediates their function in 3D genome organization.
Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicityThe authors provide the first description of the impact of reducing pdzd8-mediated mito–ER contacts which prolongs lifespan, reduces age-related locomotor decline, and protects against mitochondrial toxins. pdzd8 loss is also protective against neuronal toxicity from Aβ42.
ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1As a mechanism of crosstalk, potentially relevant to cancer and developmental signaling, ERK2 MAP kinase phosphorylates the Hedgehog-pathway transcription factor GLI1 on three sites, promoting release of the negative regulator SUFU and the consequent activation of GLI1.
The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression programThe MLL3/4 histone methyltransferase complexes and the histone deacetylase complex MiDAC regulate the histone mark H4K20ac to calibrate gene expression of a common set of target genes.
ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALFThere are at least 14 AM subtypes; their frequency, along with other immune cells, is highly conserved across individuals, suggesting a specific niche exists for each leukocyte population.
PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistancePVT1 is a YAP1 dependent stress responsive lncRNA that promotes ovarian cancer metastasis and chemoresistance, making PVT1 a promising therapeutic target.
Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in miceEnhanced autophagic activity in fibroblasts due to lack of BRAP homologous protein might contribute to the resistance to pulmonary fibrosis in mice.
KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cellsDepletion of the centrosomal kinesin KIF24, known to restrain the assembly of primary cilia, suppresses multipolar spindle formation by clustering centrosomes in centrosome-amplified PDAC cells.
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancerUsing a dual recombinase mouse model of pancreatic cancer, investigators uncover genetic evidence for the role of STAT3 signaling in cancer-associated fibroblasts in promoting tumor progression and an immunosuppressive microenvironment.