More articles from Research Articles
Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2bintron5This study investigates the axonal trafficking of the ESCRT-III protein CHMP2b and shows how the frontotemporal dementia–causative CHMP2bintron5 mutation disrupts its transport and synaptic localization.
Unraveling ADHD: genes, co-occurring traits, and developmental dynamicsIn this study, we identify genes putatively causal for ADHD and show how their biological pathways link to co-occurring traits and biomarkers in a tissue- and time-dependent manner.
Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activationThis study demonstrates the molecular mechanism and biological significance of the formation of large CSF-1 receptor aggregates in macrophages.
Canonical and non-canonical PRC1 differentially contribute to regulation of neural stem cell fateEpigenetic regulation affects the capacity of stem cells to proliferate and differentiate, with canonical PRC1 being particularly important for neural stem cell fate.
A biallelic variant in GORASP1 causes a novel Golgipathy with glycosylation and mitotic defectsThis study identifies the first human pathogenic variant in GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrates its consequences on glycosylation and mitotic progression.
PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activitiesGenome-edited cell lines for PICH depletion or replacement to loss of function mutants revealed an unidentified PICH function impacting SAC activity through modulating Bub1 association at kinetochores.
FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitisThis study sheds light on the pathogenic association between the skin and joints in psoriatic arthritis. The authors indicated that IL-17A, which is produced in the skin, induces joint manifestations via FGF7 signaling in the pathology of psoriatic arthritis.
Impaired primitive erythropoiesis and defective vascular development in Trim71-KO embryosWe report that Trim71-KO leads to decreased embryonic primitive erythropoiesis and impaired vascular development, and provide evidence for direct repression of Eomes via Trim71-mediated mRNA binding.
Unconventional receptor functions and location-biased signaling of the lactate GPCR in the nucleusHCAR1 as GPCR for Lactate is highly expressed in many cancers due to the Warburg effect. We show HCAR1 has a nuclear localization where it promotes cancer malignancy through chromatin regulation, DNA damage repair, translational regulation, and intranuclear signaling.
Sustained induction of autophagy enhances survival during prolonged starvation in newt cellsSalamanders display remarkable starvation resistance. We show that newt cells maintain constitutive activation of autophagy during prolonged starvation. This may underlie the high starvation resistance of newts and may contribute to the development of novel therapies.