More articles from Research Articles
Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regenerationA helminth-derived protein leads to rapid wound closure, skin regeneration, and reprogramming of macrophage activation through TGF-βR binding.
CC2D1A causes ciliopathy, intellectual disability, heterotaxy, renal dysplasia, and abnormal CSF flowThis report identifies two novel CC2D1A variants in patients with intellectual disability. Functional analysis in multiple model systems reveals CC2D1A’s critical role in ciliogenesis and CSF circulation.
Examining the liver–pancreas crosstalk reveals a role for the molybdenum cofactor in β-cell regenerationInvestigation of the inter-organ, pancreas–liver, crosstalk reveals a potential role of the molybdenum biosynthetic pathway in β-cell regeneration.
Enhancing uterine receptivity for embryo implantation through controlled collagenase interventionA safe and effective enzymatic pretreatment in mice enhances embryo implantation, revealing how remodeling of specific matrix components of the uterus facilitates implantation through distinct molecular mechanisms without any risk, holding clinical potential for supporting medical treatments in human reproduction.
Morphological correlates of synaptic protein turnover in the mouse brainSynapse size, vesicle numbers, or the presence of a nascent zone, are indicators for the metabolic age of the synapse, in both young adult and old mice.
Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophilsRecurrent infections are a hallmark of STAT3 DN hyper-IgE syndrome, a rare immunodeficiency syndrome, and our study suggests that neutrophil-avid nanocarriers have potential for directed delivery of cargo therapeutics to improve neutrophil infection clearance in these patients.
JAK inhibition with tofacitinib rapidly increases contractile force in human skeletal muscleInhibition of JAK activity with tofacitinib rapidly increases human skeletal muscle fiber force by up-regulating smooth muscle myosin light chain kinase, offering a new treatment for muscle weakness.
Distribution of lipid droplets in hippocampal neurons and microglia: impact of diabetes and exerciseLipid droplets (LDs) are differently distributed in the CA1 and CA3 of the mouse hippocampus, and even along the CA3. Diabetes increased microglial LDs, suggesting a neurodegenerative mechanism, which is modestly affected by high-intensity exercise.
Prenatal risk assessment of Xp21.1 duplication involving the DMD gene by optical genome mappingIt classifies the Xp21.1 duplications involving 5′-terminal DMD in prenatal case series as likely benign using OGM, which emphasizes the importance of structural evaluation on SVs involving DMD and other large dose-sensitive genes.
PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferationPPM1G inhibits cell proliferation by targeting phospho-eIF4E–dependent mRNA translation.