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More articles from Research Articles

  • RFWD3 and translesion DNA polymerases contribute to PCNA modification–dependent DNA damage tolerance
    Open Access
    RFWD3 and translesion DNA polymerases contribute to PCNA modification–dependent DNA damage tolerance

    Rie Kanao, Hidehiko Kawai, Toshiyasu Taniguchi, Minoru Takata, Chikahide Masutani

    Rie Kanao ... Chikahide Masutani

    Published 29 July 2022

    RFWD3 and the translesion DNA polymerases Polκ and Polη, for illudin S and UV DNA lesions, respectively, contribute to PCNA ubiquitination–dependent DNA damage tolerance in human cells.

  • <em>Drosophila</em> insulator proteins exhibit in vivo liquid–liquid phase separation properties
    Open Access
    Drosophila insulator proteins exhibit in vivo liquid–liquid phase separation properties

    Bright Amankwaa, Todd Schoborg, Mariano Labrador

    Bright Amankwaa ... Mariano Labrador

    Published 19 July 2022

    Drosophila insulator proteins and the cohesin subunit Rad21 coalesce in vivo to form liquid-droplet condensates, suggesting that liquid–liquid phase separation mediates their function in 3D genome organization.

  • Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ<sub>42</sub> toxicity
    Open Access
    Decreasing pdzd8-mediated mito–ER contacts improves organismal fitness and mitigates Aβ42 toxicity

    Victoria L Hewitt, Leonor Miller-Fleming, Madeleine J Twyning, Simonetta Andreazza, Francesca Mattedi, Julien Prudent, Franck Polleux, Alessio Vagnoni, Alexander J Whitworth

    Victoria L Hewitt ... Alexander J Whitworth

    Published 13 July 2022

    The authors provide the first description of the impact of reducing pdzd8-mediated mito–ER contacts which prolongs lifespan, reduces age-related locomotor decline, and protects against mitochondrial toxins. pdzd8 loss is also protective against neuronal toxicity from Aβ42.

  • ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
    Open Access
    ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

    A Jane Bardwell, Beibei Wu, Kavita Y Sarin, Marian L Waterman, Scott X Atwood, Lee Bardwell

    A Jane Bardwell ... Lee Bardwell

    Published 13 July 2022

    As a mechanism of crosstalk, potentially relevant to cancer and developmental signaling, ERK2 MAP kinase phosphorylates the Hedgehog-pathway transcription factor GLI1 on three sites, promoting release of the negative regulator SUFU and the consequent activation of GLI1.

  • The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program
    Open Access
    The MLL3/4 complexes and MiDAC co-regulate H4K20ac to control a specific gene expression program

    Xiaokang Wang, Wojciech Rosikiewicz, Yurii Sedkov, Baisakhi Mondal, Tanner Martinez, Satish Kallappagoudar, Andrey Tvardovskiy, Richa Bajpai, Beisi Xu, Shondra M Pruett-Miller, Robert Schneider, Hans-Martin Herz

    Xiaokang Wang ... Hans-Martin Herz

    Published 12 July 2022

    The MLL3/4 histone methyltransferase complexes and the histone deacetylase complex MiDAC regulate the histone mark H4K20ac to calibrate gene expression of a common set of target genes.

  • ScRNA-seq expression of <em>IFI27</em> and <em>APOC2</em> identifies four alveolar macrophage superclusters in healthy BALF
    Open Access
    ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF

    Xin Li, Fred W Kolling, Daniel Aridgides, Diane Mellinger, Alix Ashare, Claudia V Jakubzick

    Xin Li ... Claudia V Jakubzick

    Published 12 July 2022

    There are at least 14 AM subtypes; their frequency, along with other immune cells, is highly conserved across individuals, suggesting a specific niche exists for each leukocyte population.

  • PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance
    Open Access
    PVT1 is a stress-responsive lncRNA that drives ovarian cancer metastasis and chemoresistance

    Kevin Tabury, Mehri Monavarian, Eduardo Listik, Abigail K Shelton, Alex Seok Choi, Roel Quintens, Rebecca C Arend, Nadine Hempel, C Ryan Miller, Balázs Györrfy, Karthikeyan Mythreye

    Kevin Tabury ... Karthikeyan Mythreye

    Published 12 July 2022

    PVT1 is a YAP1 dependent stress responsive lncRNA that promotes ovarian cancer metastasis and chemoresistance, making PVT1 a promising therapeutic target.

  • Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice
    Open Access
    Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice

    Hui Wang, Wenrui Zhang, Rujiao Liu, Jiaoyun Zheng, Xueping Yao, Hui Chen, Jie Wang, Horst Christian Weber, Xiaoqun Qin, Yang Xiang, Chi Liu, Huijun Liu, Lang Pan, Xiangping Qu

    Hui Wang ... Xiangping Qu

    Published 12 July 2022

    Enhanced autophagic activity in fibroblasts due to lack of BRAP homologous protein might contribute to the resistance to pulmonary fibrosis in mice.

  • KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells
    Open Access
    KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells

    Yu Mashima, Hayato Nohira, Hiroki Sugihara, Brian David Dynlacht, Tetsuo Kobayashi, Hiroshi Itoh

    Yu Mashima ... Hiroshi Itoh

    Published 8 July 2022

    Depletion of the centrosomal kinesin KIF24, known to restrain the assembly of primary cilia, suppresses multipolar spindle formation by clustering centrosomes in centrosome-amplified PDAC cells.

  • STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer
    Open Access
    STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer

    Julia E Lefler, Catherine B MarElia-Bennett, Katie A Thies, Blake E Hildreth, Sudarshana M Sharma, Jason R Pitarresi, Lu Han, Caroline Everett, Christopher Koivisto, Maria C Cuitino, Cynthia D Timmers, Elizabeth O’Quinn, Melodie Parrish, Martin J Romeo, Amanda J Linke, G Aaron Hobbs, Gustavo Leone, Denis C Guttridge, Teresa A Zimmers, Gregory B Lesinski, Michael C Ostrowski

    Julia E Lefler ... Michael C Ostrowski

    Published 8 July 2022

    Using a dual recombinase mouse model of pancreatic cancer, investigators uncover genetic evidence for the role of STAT3 signaling in cancer-associated fibroblasts in promoting tumor progression and an immunosuppressive microenvironment.

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