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More articles from Research Articles

  • Epigenetic signals that direct cell type–specific interferon beta response in mouse cells
    Open Access
    Epigenetic signals that direct cell type–specific interferon beta response in mouse cells

    Markus Muckenhuber, Isabelle Seufert, Katharina Müller-Ott, Jan-Philipp Mallm, Lara C Klett, Caroline Knotz, Jana Hechler, Nick Kepper, Fabian Erdel, Karsten Rippe

    Markus Muckenhuber ... Karsten Rippe

    Published 2 February 2023

    Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction.

  • Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway
    Open Access
    Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway

    Evelyn Andrades, Agustí Toll, Gustavo Deza, Sonia Segura, Ramón Gimeno, Guadalupe Espadas, Eduard Sabidó, Noemí Haro, Óscar J Pozo, Marta Bódalo, Paloma Torres, Ramon M Pujol, Inmaculada Hernández-Muñoz

    Evelyn Andrades ... Inmaculada Hernández-Muñoz

    Published 2 February 2023

    Cholesterol metabolism may be involved in the early steps of tumor dissemination. Epigenetic regulation of cholesterol synthesis and uptake is of great importance in this process and may constitute a vulnerability of the cancer cell that could be exploited pharmacologically.

  • Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing
    Open Access
    Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencing

    Lucas Jarry, Julie Descombin, Melody Nicolau, Ange Dussutour, Nathalie Picault, Guillaume Moissiard

    Lucas Jarry ... Guillaume Moissiard

    Published 2 February 2023

    The plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.

  • Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma
    Open Access
    Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

    Véronique N Lafleur, Silvia Halim, Hani Choudhry, Peter J Ratcliffe, David R Mole

    Véronique N Lafleur ... David R Mole

    Published 1 February 2023

    This pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.

  • A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery
    Open Access
    A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery

    Patrick Essletzbichler, Vitaly Sedlyarov, Fabian Frommelt, Didier Soulat, Leonhard X Heinz, Adrijana Stefanovic, Benedikt Neumayer, Giulio Superti-Furga

    Patrick Essletzbichler ... Giulio Superti-Furga

    Published 1 February 2023

    The validation and interpretation of a genome-wide CRISRPko FACS screen via protein–protein interaction data yield a broad view of the molecular network-regulating phagocytosis in human cells.

  • The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth
    Open Access
    The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth

    Marina Badenes, Emma Burbridge, Ioanna Oikonomidi, Abdulbasit Amin, Érika de Carvalho, Lindsay Kosack, Camila Mariano, Pedro Domingos, Pedro Faísca, Colin Adrain

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    The FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.

  • The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance
    Open Access
    The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance

    Mira Brazane, Dilyana G Dimitrova, Julien Pigeon, Chiara Paolantoni, Tao Ye, Virginie Marchand, Bruno Da Silva, Elise Schaefer, Margarita T Angelova, Zornitza Stark, Martin Delatycki, Tracy Dudding-Byth, Jozef Gecz, Pierre-Yves Plaçais, Laure Teysset, Thomas Préat, Amélie Piton, Bassem A Hassan, Jean-Yves Roignant, Yuri Motorin, Clément Carré

    Mira Brazane ... Clément Carré

    Published 31 January 2023

    This study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.

  • Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling
    Open Access
    Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling

    Simran Goel, Rosario Oliva, Sadasivam Jeganathan, Verian Bader, Laura J Krause, Simon Kriegler, Isabelle D Stender, Chadwick W Christine, Ken Nakamura, Jan-Erik Hoffmann, Roland Winter, Jörg Tatzelt, Konstanze F Winklhofer

    Simran Goel ... Konstanze F Winklhofer

    Published 31 January 2023

    The E3 ubiquitin ligase HOIP generates linear ubiquitin chains that promote liquid-liquid phase separation of NEMO in vitro, which correlates with the formation of NEMO condensates and IKK complex activation in cells.

  • Mature B cells and mesenchymal stem cells control emergency myelopoiesis
    Open Access
    Mature B cells and mesenchymal stem cells control emergency myelopoiesis

    Vivian Y Lim, Xing Feng, Runfeng Miao, Sandra Zehentmeier, Nathan Ewing-Crystal, Moonyoung Lee, Alexei V Tumanov, Ji Eun Oh, Akiko Iwasaki, Andrew Wang, Jungmin Choi, João P Pereira

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    Published 30 January 2023

    Mature B cells control lymphotoxin-beta receptor signaling in mesenchymal stem cells to promote emergency myelopoiesis.

  • FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against <em>Candida albicans</em>
    Open Access
    FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans

    Rakesh Kulkarni, Siti Khadijah Kasani, Ching-Yen Tsai, Shu-Yun Tung, Kun-Hai Yeh, Chen-Hsin Albert Yu, Wen Chang

    Rakesh Kulkarni ... Wen Chang

    Published 30 January 2023

    FAM21 is essential for CD11c+ dendritic cell function to activate host immune response against C.albicans infection.

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