More articles from Research Articles
- SIRT4 as a novel interactor and candidate suppressor of C-RAF kinase in MAPK signaling
This study proposed a novel extra-mitochondrial role of the tumor suppressor SIRT4 in negatively regulating the MAPK pathway by interacting with C-RAF kinase.
- Aberrant DNA methylation distorts developmental trajectories in atypical teratoid/rhabdoid tumors
This study describes how aberrant DNA methylation–driven epigenetic regulation affects DNA binding of key transcriptions and maintains the malignant, low differentiation cell state in AT/RTs.
- CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication
This study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
- The Golgi checkpoint: Golgi unlinking during G2 is necessary for spindle formation and cytokinesis
This work shows that Golgi complex disassembly during G2 is required for spindle formation and cytokinesis, thus revealing novel regulatory mechanisms that control the fidelity of mitosis.
- Genetic ablation of Immt induces a lethal disruption of the MICOS complex
A new conditional mouse model deleting Immt/MIC60 reveals the necessity of this protein in vivo and provides an important resource for future research into the mitochondrial MICOS complex.
- Interrogating endothelial barrier regulation by temporally resolved kinase network generation
This study introduces TREKING, a methodology for broadly interrogating kinases to elucidate time-resolved functional kinase signaling networks that drive endothelial barrier disruption and recovery.
- Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Cavefish evolved protection from starvation-induced liver damage through a reduction in fatty acid uptake regulated by FATP2, a mechanism conserved through 400 million years of animal evolution.
- C5aR plus MEK inhibition durably targets the tumor milieu and reveals tumor cell phagocytosis
C5aR antagonist and MEK inhibition combination therapy changes the tumor microenvironment and induces ongoing tumor cell phagocytosis.
- Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
The recently discovered HAPSTR1 protein facilitates a nuclear quality control pathway essential for mammalian life.
- Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex
The study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis.