More articles from Research Articles
Epigenetic signals that direct cell type–specific interferon beta response in mouse cellsPreexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction.
Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathwayCholesterol metabolism may be involved in the early steps of tumor dissemination. Epigenetic regulation of cholesterol synthesis and uptake is of great importance in this process and may constitute a vulnerability of the cancer cell that could be exploited pharmacologically.
Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencingThe plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.
Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinomaThis pan-genomic study of crosstalk between HIF and AHR transcription factors reveals both antagonistic and cooperative interactions and highlights their relevance to kidney cancer and its treatment.
A genome-wide CRISPR functional survey of the human phagocytosis molecular machineryThe validation and interpretation of a genome-wide CRISRPko FACS screen via protein–protein interaction data yield a broad view of the molecular network-regulating phagocytosis in human cells.
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growthThe FERM domain protein iTAP/Frmd8, which binds to and stabilizes the ADAM17/iRhom sheddase complex at the cell surface, is a regulator of inflammation, epithelial homeostasis, and tumor growth in vivo.
The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performanceThis study adds insights into FTSJ1 tRNA 2′-O-methylation–associated pathologies in humans and Drosophila by identification of novel FTSJ1 targets and neuron morphology defects.
Linear ubiquitination induces NEMO phase separation to activate NF-κB signalingThe E3 ubiquitin ligase HOIP generates linear ubiquitin chains that promote liquid-liquid phase separation of NEMO in vitro, which correlates with the formation of NEMO condensates and IKK complex activation in cells.
Mature B cells and mesenchymal stem cells control emergency myelopoiesisMature B cells control lymphotoxin-beta receptor signaling in mesenchymal stem cells to promote emergency myelopoiesis.
FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicansFAM21 is essential for CD11c+ dendritic cell function to activate host immune response against C.albicans infection.