More articles from Research Article
NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membraneAmong the RAS isoforms, NRAS uniquely requires carboxyl methylation by ICMT for delivery to the plasma membrane because of having only a single palmitoylation as a second targeting signal.
TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibitionThe findings shed light into the adverse effects of GSIs observed in the Alzheimer’s field and explain, at least in part, the unexpected worsening in cognition observed in the semagacestat Phase 3 trial.
Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formationN-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.
Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasmsJag1 functions as a tumor suppressor in delaying pancreatic cancer precursor, while at the same time, promotes a phenotypic switch from benign cystic lesions to invasive carcinoma of the pancreas.