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Research Articles
STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programsGermline activating and deactivating mutations of STAT5b, part of the JAK-STAT signaling pathway, push the immune system and hematopoiesis in opposing directions, tuning systems either up or down.
Lipid flippases ATP9A and ATP9B form a complex and contribute to the exocytic pathway from the GolgiLipid flippases ATP9A and ATP9B form homomeric or heteromeric complexes and contribute to the exocytic pathway from the Golgi by facilitating changes in Golgi membrane curvature.
Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in Saccharomyces cerevisiaeUnlike ensemble averaging methods, this study visualizes the single molecules of Ipl1 in live yeast cells to quantify its recruitment dynamics and assembly as a part of the CPC at the kinetochores.
Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signalingThe study shows that Nrg1 nuclear signaling maintains granule cell identity and that its disruption drives acquisition of semilunar granule cell fate in the dentate gyrus.
CLCa mediates a novel cross-talk between Wnt secretion and actin organizationThe clathrin light chain, CLCa, regulates Wnt secretion in a WLS-dependent manner. Furthermore, CLCa drives actin organization and participates in its cross-talk with Wnt signaling in mammalian cells.
DNA methylation predicts infection risk in kidney transplant recipientsThis study analyzed DNA methylation perturbations in patients after kidney transplantation, revealing the infection risk can be predicted using DNA methylation profiles.
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytesInternalized HIV Tat interacts with endolysosome-resident SLC38A9 via the arginine-rich domain, and such an interaction leads to endolysosome dysfunction and cellular senescence in human astrocytes.
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylationAurora kinase A regulates kinetochore function by phosphorylating HEC1 at serine 69 in mouse oocytes undergoing completion of meiosis I, contributing to SAC activation and chromosome alignment.
Methods
Human iPS cell–derived respiratory organoids as a model for respiratory syncytial virus infectionHuman iPS cell–derived respiratory organoids can be infected with RSV, exhibiting viral replication, epithelial damage, and immune responses, providing a physiologically relevant model for RSV research.
