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About the Cover

July 2025 | Volume 8, No. 7

Research Articles

  • STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
    Open Access
    STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

    Hye Kyung Lee, Jichun Chen, Rachael L Philips, Sung-Gwon Lee, Xingmin Feng, Zhijie Wu, Chengyu Liu, Aaron B Schultz, Molly Dalzell, Manja Meggendorfer, Claudia Haferlach, Foster Birnbaum, Joel A Sexton, Amy E Keating, John J O’Shea, Neal S Young, Alejandro V Villarino, Priscilla A Furth, Lothar Hennighausen

    Hye Kyung Lee ... Lothar Hennighausen

    Published 14 April 2025

    Germline activating and deactivating mutations of STAT5b, part of the JAK-STAT signaling pathway, push the immune system and hematopoiesis in opposing directions, tuning systems either up or down.

  • Lipid flippases ATP9A and ATP9B form a complex and contribute to the exocytic pathway from the Golgi
    Open Access
    Lipid flippases ATP9A and ATP9B form a complex and contribute to the exocytic pathway from the Golgi

    Tsukasa Yagi, Riki Nakabuchi, Yumeka Muranaka, Gaku Tanaka, Yohei Katoh, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin

    Tsukasa Yagi ... Hye-Won Shin

    Published 15 April 2025

    Lipid flippases ATP9A and ATP9B form homomeric or heteromeric complexes and contribute to the exocytic pathway from the Golgi by facilitating changes in Golgi membrane curvature.

  • Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in <em>Saccharomyces cerevisiae</em>
    Open Access
    Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in Saccharomyces cerevisiae

    Nitesh Kumar Podh, Ayan Das, Akriti Kumari, Kirti Garg, Rashmi Yadav, Kirti Kashyap, Sahil Islam, Anupam Gupta, Gunjan Mehta

    Nitesh Kumar Podh ... Gunjan Mehta

    Published 18 April 2025

    Unlike ensemble averaging methods, this study visualizes the single molecules of Ipl1 in live yeast cells to quantify its recruitment dynamics and assembly as a part of the CPC at the kinetochores.

  • Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling
    Open Access
    Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling

    Prithviraj Rajebhosale, Li Jiang, Haylee J Ressa, Kory R Johnson, Niraj S Desai, Alice Jone, Lorna W Role, David A Talmage

    Prithviraj Rajebhosale ... David A Talmage

    Published 25 April 2025

    The study shows that Nrg1 nuclear signaling maintains granule cell identity and that its disruption drives acquisition of semilunar granule cell fate in the dentate gyrus.

  • CLCa mediates a novel cross-talk between Wnt secretion and actin organization
    Open Access
    CLCa mediates a novel cross-talk between Wnt secretion and actin organization

    Mahak Tiwari, Mihir Dingankar, Jyoti Das, Sreelekshmi S R, Apurv Solanki, Deepa Subramanyam

    Mahak Tiwari ... Deepa Subramanyam

    Published 2 May 2025

    The clathrin light chain, CLCa, regulates Wnt secretion in a WLS-dependent manner. Furthermore, CLCa drives actin organization and participates in its cross-talk with Wnt signaling in mammalian cells.

  • DNA methylation predicts infection risk in kidney transplant recipients
    Open Access
    DNA methylation predicts infection risk in kidney transplant recipients

    Fei-Man Hsu, Harry Pickering, Liudmilla Rubbi, Michael Thompson, Elaine F Reed, Matteo Pellegrini, Joanna M Schaenman

    Fei-Man Hsu ... Joanna M Schaenman

    Published 5 May 2025

    This study analyzed DNA methylation perturbations in patients after kidney transplantation, revealing the infection risk can be predicted using DNA methylation profiles.

  • SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes
    Open Access
    SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes

    Neda Rezagholizadeh, Gaurav Datta, Wendie A Hasler, Erica C Nguon, Elise V Smokey, Nabab Khan, Xuesong Chen

    Neda Rezagholizadeh ... Xuesong Chen

    Published 5 May 2025

    Internalized HIV Tat interacts with endolysosome-resident SLC38A9 via the arginine-rich domain, and such an interaction leads to endolysosome dysfunction and cellular senescence in human astrocytes.

  • AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation
    Open Access
    AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation

    Cecilia S Blengini, Shuang Tang, Robert J Mendola, G John Garrisi, Jason E Swain, Karen Schindler

    Cecilia S Blengini ... Karen Schindler

    Published 6 May 2025

    Aurora kinase A regulates kinetochore function by phosphorylating HEC1 at serine 69 in mouse oocytes undergoing completion of meiosis I, contributing to SAC activation and chromosome alignment.

Methods

  • Human iPS cell–derived respiratory organoids as a model for respiratory syncytial virus infection
    Open Access
    Human iPS cell–derived respiratory organoids as a model for respiratory syncytial virus infection

    Rina Hashimoto, Yukio Watanabe, Abeer Keshta, Masaya Sugiyama, Yuki Kitai, Ai Hirabayashi, Naoko Yasuhara, Shiho Morimoto, Ayaka Sakamoto, Yasufumi Matsumura, Hidekazu Nishimura, Takeshi Noda, Takuya Yamamoto, Miki Nagao, Makoto Takeda, Kazuo Takayama

    Rina Hashimoto ... Kazuo Takayama

    Published 22 April 2025

    Human iPS cell–derived respiratory organoids can be infected with RSV, exhibiting viral replication, epithelial damage, and immune responses, providing a physiologically relevant model for RSV research.

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In this Issue

Volume 8, No. 7
July 2025
  • Table of Contents
  • Cover (PDF)
  • About the Cover
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