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Research Article
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Plasmacytoid dendritic cell sensing of hepatitis E virus is shaped by both viral and host factors

View ORCID ProfileGarima Joshi  Correspondence email, View ORCID ProfileElodie Décembre, Jacques Brocard, Claire Montpellier, View ORCID ProfileMartin Ferrié, View ORCID ProfileOmran Allatif, View ORCID ProfileAnn-Kathrin Mehnert, View ORCID ProfileJohann Pons, View ORCID ProfileDelphine Galiana, View ORCID ProfileViet Loan Dao Thi, View ORCID ProfileNolwenn Jouvenet, View ORCID ProfileLaurence Cocquerel, View ORCID ProfileMarlène Dreux  Correspondence email
Garima Joshi
1CIRI, INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University Lyon, Lyon, France
Roles: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Garima Joshi
  • For correspondence: garima.joshi@ens-lyon.fr
Elodie Décembre
1CIRI, INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University Lyon, Lyon, France
Roles: Investigation, Methodology
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  • ORCID record for Elodie Décembre
Jacques Brocard
2Université Claude Bernard Lyon 1, CNRS UAR3444, INSERMUS8, ENS de Lyon, SFR Biosciences, Lyon, France
Roles: Formal analysis, Validation, Methodology
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Claire Montpellier
3University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France
Roles: Resources, Investigation, Methodology
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Martin Ferrié
3University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France
Roles: Resources, Investigation, Methodology
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  • ORCID record for Martin Ferrié
Omran Allatif
1CIRI, INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University Lyon, Lyon, France
Roles: Formal analysis, Validation
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  • ORCID record for Omran Allatif
Ann-Kathrin Mehnert
5Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany and German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany
Roles: Investigation
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  • ORCID record for Ann-Kathrin Mehnert
Johann Pons
6Sup’biotech, École Des Ingénieurs En Biotechnologies, Villejuif, Paris
Roles: Investigation
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  • ORCID record for Johann Pons
Delphine Galiana
1CIRI, INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University Lyon, Lyon, France
Roles: Formal analysis, Supervision, Investigation, Writing—review and editing
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Viet Loan Dao Thi
5Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany and German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany
Roles: Resources, Supervision, Methodology, Writing—review and editing
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Nolwenn Jouvenet
4Institut Pasteur, Université de Paris, CNRS UMR 3569, Virus sensing and signaling Unit, Paris, France
Roles: Formal analysis, Supervision, Validation, Writing—review and editing
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Laurence Cocquerel
3University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France
Roles: Conceptualization, Resources, Formal analysis, Supervision, Validation, Methodology, Writing—review and editing
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Marlène Dreux
1CIRI, INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University Lyon, Lyon, France
Roles: Conceptualization, Supervision, Funding acquisition, Writing—original draft, Writing—review and editing
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  • ORCID record for Marlène Dreux
  • For correspondence: garima.joshi@ens-lyon.fr
Published 2 April 2025. DOI: 10.26508/lsa.202503256
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Article Information

vol. 8 no. 6 e202503256
DOI 
https://doi.org/10.26508/lsa.202503256
PubMed 
40175091

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received February 6, 2025
  • Revision received March 14, 2025
  • Accepted March 14, 2025
  • Published online April 2, 2025.

Copyright & Usage 
© 2025 Joshi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Garima Joshi1⇑, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Writing—original draft, Writing—review and editing,
  2. Elodie Décembre1, Investigation, Methodology,
  3. Jacques Brocard2, Formal analysis, Validation, Methodology,
  4. Claire Montpellier3, Resources, Investigation, Methodology,
  5. Martin Ferrié3, Resources, Investigation, Methodology,
  6. Omran Allatif1, Formal analysis, Validation,
  7. Ann-Kathrin Mehnert5, Investigation,
  8. Johann Pons6, Investigation,
  9. Delphine Galiana1, Formal analysis, Supervision, Investigation, Writing—review and editing,
  10. Viet Loan Dao Thi5, Resources, Supervision, Methodology, Writing—review and editing,
  11. Nolwenn Jouvenet4, Formal analysis, Supervision, Validation, Writing—review and editing,
  12. Laurence Cocquerel3, Conceptualization, Resources, Formal analysis, Supervision, Validation, Methodology, Writing—review and editing and
  13. Marlène Dreux1⇑, Conceptualization, Supervision, Funding acquisition, Writing—original draft, Writing—review and editing
  1. 1CIRI, INSERM, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, University Lyon, Lyon, France
  2. 2Université Claude Bernard Lyon 1, CNRS UAR3444, INSERMUS8, ENS de Lyon, SFR Biosciences, Lyon, France
  3. 3University Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, U1019-UMR 9017-CIIL-Center for Infection and Immunity of Lille, Lille, France
  4. 4Institut Pasteur, Université de Paris, CNRS UMR 3569, Virus sensing and signaling Unit, Paris, France
  5. 5Department of Infectious Diseases, Virology, Heidelberg University, Medical Faculty Heidelberg, Heidelberg, Germany and German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany
  6. 6Sup’biotech, École Des Ingénieurs En Biotechnologies, Villejuif, Paris
  1. Correspondence: garima.joshi{at}ens-lyon.fr
  2. marlene.dreux{at}ens-lyon.fr
  • Marlène Dreux died on March 18, 2025

View Full Text

Funding

  • Agence Nationale de la Recherche

    ANRJCJC-iSYN
  • Agence Nationale pour la Recherche contre le SIDA et les Hépatites Virales

    ANRS – N21006CR, N19017CR
  • UDL/ANR IA ELAN ERC

    G19005CC
    M Dreux
  • Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)

    272983813 SFB/TRR 179
    VL Dao Thi, A-K Mehnert
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PDC’s healing touch is fundamental to fight HEV infection
Garima Joshi, Elodie Décembre, Jacques Brocard, Claire Montpellier, Martin Ferrié, Omran Allatif, Ann-Kathrin Mehnert, Johann Pons, Delphine Galiana, Viet Loan Dao Thi, Nolwenn Jouvenet, Laurence Cocquerel, Marlène Dreux
Life Science Alliance Apr 2025, 8 (6) e202503256; DOI: 10.26508/lsa.202503256

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PDC’s healing touch is fundamental to fight HEV infection
Garima Joshi, Elodie Décembre, Jacques Brocard, Claire Montpellier, Martin Ferrié, Omran Allatif, Ann-Kathrin Mehnert, Johann Pons, Delphine Galiana, Viet Loan Dao Thi, Nolwenn Jouvenet, Laurence Cocquerel, Marlène Dreux
Life Science Alliance Apr 2025, 8 (6) e202503256; DOI: 10.26508/lsa.202503256
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Volume 8, No. 6
June 2025
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