Cytokine storm and vascular leakage in severe dengue: insights from single-cell RNA profiling

Mohamad Al Kadi; Maika Yamashita; Masayuki Shimojima; Tomoki Yoshikawa; Hideki Ebihara; Daisuke Okuzaki; Takeshi Kurosu

doi:10.26508/lsa.202403008

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Cytokine storm and vascular leakage in severe dengue: insights from single-cell RNA profiling

View ORCID ProfileMohamad Al Kadi, Maika Yamashita, Masayuki Shimojima, Tomoki Yoshikawa, Hideki Ebihara, View ORCID ProfileDaisuke Okuzaki Correspondence email, View ORCID ProfileTakeshi Kurosu Correspondence email

Mohamad Al Kadi

1Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

Roles: Conceptualization, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing

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ORCID record for Mohamad Al Kadi

Maika Yamashita

1Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

Roles: Data curation, Methodology, Writing—review and editing

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Masayuki Shimojima

2Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

Roles: Methodology, Writing—review and editing

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Tomoki Yoshikawa

2Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

Roles: Methodology, Writing—review and editing

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Hideki Ebihara

2Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

Roles: Conceptualization, Writing—review and editing

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Daisuke Okuzaki

1Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

Roles: Conceptualization, Resources, Software, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Project administration, Writing—review and editing

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ORCID record for Daisuke Okuzaki
For correspondence: dokuzaki@biken.osaka-u.ac.jp

Takeshi Kurosu

2Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan

Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for Takeshi Kurosu
For correspondence: kurosu@niid.go.jp

Published 24 March 2025. DOI: 10.26508/lsa.202403008

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RNA profile by single cell analysis of severe dengue in mice

Mohamad Al Kadi, Maika Yamashita, Masayuki Shimojima, Tomoki Yoshikawa, Hideki Ebihara, Daisuke Okuzaki, Takeshi Kurosu

Life Science Alliance Mar 2025, 8 (6) e202403008; DOI: 10.26508/lsa.202403008

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RNA profile by single cell analysis of severe dengue in mice

Mohamad Al Kadi, Maika Yamashita, Masayuki Shimojima, Tomoki Yoshikawa, Hideki Ebihara, Daisuke Okuzaki, Takeshi Kurosu

Life Science Alliance Mar 2025, 8 (6) e202403008; DOI: 10.26508/lsa.202403008

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