TPX2 lactylation is required for the cell cycle regulation and hepatocellular carcinoma progression

Shengzhi Liu; Jin Cai; Xiaoyu Qian; Junjiao Zhang; Yi Zhang; Xiang Meng; Mingjie Wang; Ping Gao; Xiuying Zhong

doi:10.26508/lsa.202402978

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TPX2 lactylation is required for the cell cycle regulation and hepatocellular carcinoma progression

Shengzhi Liu, View ORCID ProfileJin Cai, Xiaoyu Qian, Junjiao Zhang, Yi Zhang, Xiang Meng, Mingjie Wang, View ORCID ProfilePing Gao Correspondence email, View ORCID ProfileXiuying Zhong Correspondence email

Shengzhi Liu

1School of Medicine, South China University of Technology, Guangzhou, China

Roles: Conceptualization, Data curation, Software, Formal analysis, Validation, Investigation, Visualization

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Jin Cai

2Medical Research Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China

Roles: Conceptualization, Data curation, Software, Validation, Investigation

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ORCID record for Jin Cai

Xiaoyu Qian

1School of Medicine, South China University of Technology, Guangzhou, China

2Medical Research Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China

Roles: Software, Methodology

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Junjiao Zhang

3School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China

Roles: Software, Investigation

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Yi Zhang

1School of Medicine, South China University of Technology, Guangzhou, China

Roles: Software, Visualization

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Xiang Meng

1School of Medicine, South China University of Technology, Guangzhou, China

Roles: Software, Formal analysis

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Mingjie Wang

1School of Medicine, South China University of Technology, Guangzhou, China

Roles: Software, Visualization

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Ping Gao

1School of Medicine, South China University of Technology, Guangzhou, China

2Medical Research Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China

3School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China

Roles: Conceptualization, Resources

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ORCID record for Ping Gao
For correspondence: pgao2@ustc.edu.cn

Xiuying Zhong

1School of Medicine, South China University of Technology, Guangzhou, China

2Medical Research Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China

Roles: Conceptualization, Resources, Methodology

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ORCID record for Xiuying Zhong
For correspondence: zxywawj@ustc.edu.cn

Published 19 March 2025. DOI: 10.26508/lsa.202402978

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TPX2 lactylation promotes tumorigenesis

Shengzhi Liu, Jin Cai, Xiaoyu Qian, Junjiao Zhang, Yi Zhang, Xiang Meng, Mingjie Wang, Ping Gao, Xiuying Zhong

Life Science Alliance Mar 2025, 8 (6) e202402978; DOI: 10.26508/lsa.202402978

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TPX2 lactylation promotes tumorigenesis

Shengzhi Liu, Jin Cai, Xiaoyu Qian, Junjiao Zhang, Yi Zhang, Xiang Meng, Mingjie Wang, Ping Gao, Xiuying Zhong

Life Science Alliance Mar 2025, 8 (6) e202402978; DOI: 10.26508/lsa.202402978

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