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Table of Contents

May 2025 | Volume 8, No. 5

Editorials

  • Message from the new Executive Editor
    Open Access
    Message from the new Executive Editor

    Tim Fessenden

    Tim Fessenden

    Published 22 April 2025

    Tim Fessenden introduces himself as Executive Editor of LSA, shares his view of what editors actually do, and remarks on the current systemic challenges to research funding.

Research Articles

  • Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activation
    Open Access
    Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activation

    Randa A Abdelnaser, Masateru Hiyoshi, Naofumi Takahashi, Youssef M Eltalkhawy, Hidenobu Mizuno, Shunsuke Kimura, Koji Hase, Hiroshi Ohno, Kazuaki Monde, Akira Ono, Shinya Suzu

    Randa A Abdelnaser ... Shinya Suzu

    Published 12 February 2025

    This study demonstrates the molecular mechanism and biological significance of the formation of large CSF-1 receptor aggregates in macrophages.

  • Unraveling ADHD: genes, co-occurring traits, and developmental dynamics
    Open Access
    Unraveling ADHD: genes, co-occurring traits, and developmental dynamics

    Catriona J Miller, Evgeniia Golovina, Sreemol Gokuladhas, Joerg S Wicker, Jessie C Jacobsen, Justin M O’Sullivan

    Catriona J Miller ... Justin M O’Sullivan

    Published 25 February 2025

    In this study, we identify genes putatively causal for ADHD and show how their biological pathways link to co-occurring traits and biomarkers in a tissue- and time-dependent manner.

  • Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2b<sup>intron5</sup>
    Open Access
    Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2bintron5

    Konner R Kirwan, Veria Puerta-Alvarado, Clarissa L Waites

    Konner R Kirwan ... Clarissa L Waites

    Published 28 February 2025

    This study investigates the axonal trafficking of the ESCRT-III protein CHMP2b and shows how the frontotemporal dementia–causative CHMP2bintron5 mutation disrupts its transport and synaptic localization.

  • Metabolic dysregulation contributes to the development of dysferlinopathy
    Open Access
    Metabolic dysregulation contributes to the development of dysferlinopathy

    Regula Furrer, Sedat Dilbaz, Stefan A Steurer, Gesa Santos, Bettina Karrer-Cardel, Danilo Ritz, Michael Sinnreich, Christoph Handschin

    Regula Furrer ... Christoph Handschin

    Published 28 February 2025

    Dysferlin deficiency causes metabolic dysregulation, characterized by mitochondrial abnormalities, death signaling, and elevated glucose uptake and excessive glycogen accumulation in muscle.

  • An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
    Open Access
    An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation

    Mónica Román-Trufero, Istvan T Kleijn, Kevin Blighe, Jinglin Zhou, Paula Saavedra-García, Abigail Gaffar, Marilena Christoforou, Axel Bellotti, Joel Abrahams, Abdelmadjid Atrih, Douglas Lamont, Marek Gierlinski, Pooja Jayaprakash, Audrey M Michel, Eric O Aboagye, Mariia Yuneva, Glenn R Masson, Vahid Shahrezaei, Holger W Auner

    Mónica Román-Trufero ... Holger W Auner

    Published 3 March 2025

    GCN2 restrains ribosome biogenesis at mRNA and translational levels, keeps protein synthesis in check, and maintains metabolic homeostasis independently of the ISR in a subset of cancers.

  • MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks
    Open Access
    MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks

    Mònica Torres Esteban, Matthew J Stewart, Eilis Bragginton, Alice Meroni, Annica Pellizzari, Alain Jeanrenaud, Stephen J Smerdon, Manuel Stucki

    Mònica Torres Esteban ... Manuel Stucki

    Published 6 March 2025

    RING E3 ubiquitin ligases Pellino 1 and 2 are recruited to sites of DNA damage via their non-canonical FHA domains that recognise conserved phosphorylated sequence motifs in the DNA damage adaptor protein MDC1.

  • Mechanical forces and ligand binding modulate <em>Pseudomonas aeruginosa</em> PilY1 mechanosensitive protein
    Open Access
    Mechanical forces and ligand binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive protein

    Francisco J Cao-Garcia, Jane E Walker, Stephanie Board, Alvaro Alonso-Caballero

    Francisco J Cao-Garcia ... Alvaro Alonso-Caballero

    Published 7 March 2025

    Single-molecule experiments reveal that PilY1’s behavior changes with force load and ligand binding, allowing for the mechanical compartmentalization of its functions.

  • The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis
    Open Access
    The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis

    Georg Jocher, Gozde Ozcelik, Stephan A Müller, Hung-En Hsia, Miranda Lastra Osua, Laura I Hofmann, Marlene Aßfalg, Lina Dinkel, Xiao Feng, Kai Schlepckow, Michael Willem, Christian Haass, Sabina Tahirovic, Carl P Blobel, Stefan F Lichtenthaler

    Georg Jocher ... Stefan F Lichtenthaler

    Published 13 March 2025

    This study demonstrates that the Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis and establishes ADAM17 as a physiological TREM2 protease in microglia.

  • Lipid-driven Src self-association modulates its transformation capacity
    Open Access
    Lipid-driven Src self-association modulates its transformation capacity

    Irrem-Laareb Mohammad, Marina I Giannotti, Elise Fourgous, Yvan Boublik, Alejandro Fernández, Anabel-Lise Le Roux, Audrey Sirvent, Marta Taulés, Serge Roche, Miquel Pons

    Irrem-Laareb Mohammad ... Miquel Pons

    Published 13 March 2025

    Lipid-mediated condensates formed by Src on supported lipid membranes are dependent of a conserved lysine cluster in its SH4 domain and modulate its transforming capacity.

Methods

  • Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage display
    Open Access
    Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage display

    Toini Pemmari, Stuart Prince, Niklas Wiss, Kuldar Kõiv, Ulrike May, Tarmo Mölder, Aleksander Sudakov, Fernanda Munoz Caro, Soili Lehtonen, Hannele Uusitalo-Järvinen, Tambet Teesalu, Tero AH Järvinen

    Toini Pemmari ... Tero AH Järvinen

    Published 11 February 2025

    In vivo phage display combined with microdialysis can be used for the discovery of vascular homing peptides capable of extravasation and tissue penetration in the target organ.

  • Reversible and effective cell cycle synchronization method for studying stage-specific processes
    Open Access
    Reversible and effective cell cycle synchronization method for studying stage-specific processes

    Yu-Lin Chen, Syon Reddy, Aussie Suzuki

    Yu-Lin Chen ... Aussie Suzuki

    Published 4 March 2025

    Reversible and effective cell cycle synchronization (CellSync).

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In this Issue

Volume 8, No. 5
May 2025
  • Table of Contents
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  • About the Cover
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