Table of Contents
Editorials
Message from the new Executive EditorTim Fessenden introduces himself as Executive Editor of LSA, shares his view of what editors actually do, and remarks on the current systemic challenges to research funding.
Research Articles
Identification of TNFAIP2 as a unique cellular regulator of CSF-1 receptor activationThis study demonstrates the molecular mechanism and biological significance of the formation of large CSF-1 receptor aggregates in macrophages.
Unraveling ADHD: genes, co-occurring traits, and developmental dynamicsIn this study, we identify genes putatively causal for ADHD and show how their biological pathways link to co-occurring traits and biomarkers in a tissue- and time-dependent manner.
Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2bintron5This study investigates the axonal trafficking of the ESCRT-III protein CHMP2b and shows how the frontotemporal dementia–causative CHMP2bintron5 mutation disrupts its transport and synaptic localization.
Metabolic dysregulation contributes to the development of dysferlinopathyDysferlin deficiency causes metabolic dysregulation, characterized by mitochondrial abnormalities, death signaling, and elevated glucose uptake and excessive glycogen accumulation in muscle.
An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translationGCN2 restrains ribosome biogenesis at mRNA and translational levels, keeps protein synthesis in check, and maintains metabolic homeostasis independently of the ISR in a subset of cancers.
MDC1 mediates Pellino recruitment to sites of DNA double-strand breaksRING E3 ubiquitin ligases Pellino 1 and 2 are recruited to sites of DNA damage via their non-canonical FHA domains that recognise conserved phosphorylated sequence motifs in the DNA damage adaptor protein MDC1.
Mechanical forces and ligand binding modulate Pseudomonas aeruginosa PilY1 mechanosensitive proteinSingle-molecule experiments reveal that PilY1’s behavior changes with force load and ligand binding, allowing for the mechanical compartmentalization of its functions.
The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysisThis study demonstrates that the Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis and establishes ADAM17 as a physiological TREM2 protease in microglia.
Lipid-driven Src self-association modulates its transformation capacityLipid-mediated condensates formed by Src on supported lipid membranes are dependent of a conserved lysine cluster in its SH4 domain and modulate its transforming capacity.
Methods
Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage displayIn vivo phage display combined with microdialysis can be used for the discovery of vascular homing peptides capable of extravasation and tissue penetration in the target organ.
Reversible and effective cell cycle synchronization method for studying stage-specific processesReversible and effective cell cycle synchronization (CellSync).
