Research Article


Open Access
N-6-methyladenosine (m6A) promotes the nuclear retention of mRNAs with intact 5′ splice site motifs
Eliza S Lee, Harrison W Smith, Yifan E Wang, Sean SJ Ihn, Leticia Scalize de Oliveira, Nevraj S Kejiou, Yijing L Liang, Syed Nabeel-Shah, View ORCID ProfileRobert Y Jomphe, Shuye Pu, View ORCID ProfileJack F Greenblatt, View ORCID ProfileAlexander F Palazzo Correspondence email
Eliza S Lee
1Department of Biochemistry, University of Toronto, Toronto, Canada
Roles: Conceptualization, Investigation, Writing—original draft, Writing—review and editing
Harrison W Smith
1Department of Biochemistry, University of Toronto, Toronto, Canada
Roles: Investigation
Yifan E Wang
1Department of Biochemistry, University of Toronto, Toronto, Canada
Roles: Investigation
Sean SJ Ihn
1Department of Biochemistry, University of Toronto, Toronto, Canada
Roles: Investigation
Leticia Scalize de Oliveira
1Department of Biochemistry, University of Toronto, Toronto, Canada
Roles: Investigation
Nevraj S Kejiou
1Department of Biochemistry, University of Toronto, Toronto, Canada
Roles: Investigation
Yijing L Liang
2Centre for Computational Medicine, Hospital for Sick Children, Toronto, Canada
Roles: Investigation
Syed Nabeel-Shah
3Department of Molecular Genetics, University of Toronto, Toronto, Canada
4Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Canada
Roles: Investigation
Robert Y Jomphe
1Department of Biochemistry, University of Toronto, Toronto, Canada
5Cell Biology Program, Hospital for Sick Children, Toronto, Canada
Roles: Data curation, Investigation
Shuye Pu
4Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Canada
Roles: Data curation, Investigation
Jack F Greenblatt
3Department of Molecular Genetics, University of Toronto, Toronto, Canada
4Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Canada
Roles: Resources, Supervision
Alexander F Palazzo
1Department of Biochemistry, University of Toronto, Toronto, Canada
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Investigation, Writing—original draft, Project administration, Writing—review and editing
Published 3 December 2024. DOI: 10.26508/lsa.202403142
m6A mediates the nuclear retention of mRNAs with 5′SS motifs
Eliza S Lee, Harrison W Smith, Yifan E Wang, Sean SJ Ihn, Leticia Scalize de Oliveira, Nevraj S Kejiou, Yijing L Liang, Syed Nabeel-Shah, Robert Y Jomphe, Shuye Pu, Jack F Greenblatt, Alexander F Palazzo
Life Science Alliance Dec 2024, 8 (2) e202403142; DOI: 10.26508/lsa.202403142
m6A mediates the nuclear retention of mRNAs with 5′SS motifs
Eliza S Lee, Harrison W Smith, Yifan E Wang, Sean SJ Ihn, Leticia Scalize de Oliveira, Nevraj S Kejiou, Yijing L Liang, Syed Nabeel-Shah, Robert Y Jomphe, Shuye Pu, Jack F Greenblatt, Alexander F Palazzo
Life Science Alliance Dec 2024, 8 (2) e202403142; DOI: 10.26508/lsa.202403142
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Volume 8, No. 2
February 2025
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