Targeting TREM2 signaling shows limited impact on cerebrovascular calcification

Sucheta Sridhar; Yingyue Zhou; Adiljan Ibrahim; Sergio Bertazzo; Tania Wyss; Amanda Swain; Upasana Maheshwari; Sheng-Fu Huang; Marco Colonna; Annika Keller

doi:10.26508/lsa.202402796

Research Article

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Targeting TREM2 signaling shows limited impact on cerebrovascular calcification

View ORCID ProfileSucheta Sridhar, View ORCID ProfileYingyue Zhou, Adiljan Ibrahim, View ORCID ProfileSergio Bertazzo, View ORCID ProfileTania Wyss, Amanda Swain, View ORCID ProfileUpasana Maheshwari, View ORCID ProfileSheng-Fu Huang, View ORCID ProfileMarco Colonna, View ORCID ProfileAnnika Keller Correspondence email

Sucheta Sridhar

1Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland

2Neuroscience Centre Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

Roles: Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing

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Yingyue Zhou

3Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA

Roles: Data curation, Formal analysis, Investigation, Methodology

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ORCID record for Yingyue Zhou

Adiljan Ibrahim

4Alector, South San Francisco, CA, USA

Roles: Data curation, Formal analysis, Investigation, Methodology

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Sergio Bertazzo

5Department of Medical Physics and Biomedical Engineering, University College London, London, UK

Roles: Data curation, Formal analysis, Investigation, Methodology

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ORCID record for Sergio Bertazzo

Tania Wyss

6TDS-facility, AGORA Cancer Research Center, Swiss Institute of Bioinformatics, Lausanne, Switzerland

Roles: Data curation, Software, Formal analysis, Investigation

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Amanda Swain

3Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA

Roles: Data curation, Investigation, Methodology

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Upasana Maheshwari

1Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Roles: Data curation, Formal analysis, Investigation, Methodology

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ORCID record for Upasana Maheshwari

Sheng-Fu Huang

1Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Roles: Data curation, Formal analysis, Investigation, Methodology

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ORCID record for Sheng-Fu Huang

Marco Colonna

3Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA

Roles: Resources, Supervision, Resources, Supervision, Resources, Supervision

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ORCID record for Marco Colonna

Annika Keller

1Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland

2Neuroscience Centre Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

Roles: Conceptualization, Resources, Formal analysis, Supervision, Funding acquisition, Investigation, Methodology, Writing—original draft, Project administration, Writing—review and editing

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For correspondence: annika.keller@usz.ch

Published 28 October 2024. DOI: 10.26508/lsa.202402796

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TREM2 activation is insufficient to clear brain calcification

Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller

Life Science Alliance Oct 2024, 8 (1) e202402796; DOI: 10.26508/lsa.202402796

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TREM2 activation is insufficient to clear brain calcification

Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller

Life Science Alliance Oct 2024, 8 (1) e202402796; DOI: 10.26508/lsa.202402796

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