Table of Contents
Research Articles
Microglia are essential for tissue contraction in wound closure after brain injury in zebrafish larvaeAlthough in humans, the brain fails to heal after an injury, young zebrafish are able to restore tissue structural integrity in less than 24 h, thanks to the mechanical action of microglia.
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregationGenerating various CENP-C mutant cell lines, Kong et al demonstrated that there is a positive regulatory loop between Aurora B recruitment and the CENP-C-Mis12C interaction at kinetochores in mammalian cells.
SNX5 promotes antigen presentation in B cells by dual regulation of actin and lysosomal dynamicsB cells form SNX5-rich protrusions at the plasma membrane, which dissipate upon interaction with soluble antigens. SNX5 accumulates at the immune synapse regulating actin-dependent spreading responses. SNX5 regulates endolysosomal trafficking required to promote antigen extraction and presentation.
Structural and biochemical analysis of ligand binding in yeast Niemann–Pick type C1–related proteinResults of X-ray crystallography and binding assays with different lipids expand our knowledge of the substrate scope of the Niemann–Pick type C1–related proteins NCR1 and NPC2 in yeast.
Targeting TREM2 signaling shows limited impact on cerebrovascular calcificationMicroglia protect the brain from calcification and require the TREM2 receptor for this role. Here, we find that boosting TREM2 function using an antibody increases a TREM2-dependent response of microglia to vascular calcifications but is insufficient to resolve the pathology.
BACH1 as a key driver in rheumatoid arthritis fibroblast-like synoviocytes identified through gene network analysisThe study identifies BACH1 as a key driver of fibroblast-like synoviocyte pathogenicity in rheumatoid arthritis, highlighting its role in regulating fatty acid metabolism and ferroptosis.
Decoupling actin assembly from microtubule disassembly by TBC1D3C-mediated direct GEF-H1 activationOur findings reveal a novel mechanism whereby actin filament assembly is decoupled from microtubule disassembly, providing insights into the intricate regulation of the cytoskeleton.
PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophyOur study identifies PTPN1/2 as potential therapeutic targets for Duchenne muscular dystrophy and suggests the use of PTPN1/2 inhibitors to enhance the myogenic function of DMD muscle stem cells.
Antigen-specific modulation of chronic experimental autoimmune encephalomyelitis in humanized mice by TCR-like antibody targeting autoreactive T-cell epitopeTCR-like antibodies mediate the therapeutic effect of EAE/MS.
Notch signaling mediates between two pattern-forming processes during head regeneration in HydraIn Hydra, Notch is required for head regeneration to harmonize two signaling and transcription factor modules for reforming two independent structures—a hypostome and a ring of tentacles; Craspedacusta polyps, in contrast, regenerate their tentacle-less heads independently of Notch.
Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneuronsParvalbumin interneurons in the dorsal striatum lose primary cilia in mice and humans harboring Parkinson’s disease–associated, activating mutations in LRRK2 kinase, resulting in loss of hedgehog signaling and decreased production of neuroprotective Neurturin to support dopamine neurons.
Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in miceThis study shows how necroptotic effector MLKL can induce obesity and perturb lipid metabolism to drive MAFLD progression, independent of RIPK3 that regulates inflammatory events.
Transcriptional regulators ensuring specific gene expression and decision-making at high TGFβ dosesA systems biology approach integrates measurements of TGFβ-induced signaling, gene expression, and fate decisions to reveal mechanisms of dose-dependent decoding of input signals in gene regulation.
Methods
Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironmentObserving early metastases in vivo is virtually impossible, and most culture systems lack the conditions that tumor cells encounter early in the metastatic process. We thus developed the 3MIC—an ex vivo cell culture system—allowing the direct observation of nascent metastases.
Corrections
- Correction: Gene expression and chromatin conformation of microglia in virally suppressed people with HIV
Leveraging our rapid autopsy “Last Gift” cohort at UCSD, we identified distinct microglial gene expression profiles despite ART.
Resources
Mass spectrometry–based proteomic exploration of diverse murine macrophage cellular modelsIn this article, we characterised multiple murine macrophage cell models by proteomics and identified significant differences compared with bone marrow–derived macrophages.
