Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity

Andrea Orsi; Eelco van Anken; Milena Vitale; Moreno Zamai; Valeria R Caiolfa; Roberto Sitia; Anush Bakunts

doi:10.26508/lsa.202302562

Research Article

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Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity

Andrea Orsi, Eelco van Anken, Milena Vitale, View ORCID ProfileMoreno Zamai, Valeria R Caiolfa, View ORCID ProfileRoberto Sitia Correspondence email, View ORCID ProfileAnush Bakunts Correspondence email

Andrea Orsi

1Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy

Roles: Data curation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing

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Eelco van Anken

2Division of Genetics and Cell Biology, Vita-Salute San Raffaele University, Milan, Italy

Roles: Conceptualization, Supervision, Methodology

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Milena Vitale

2Division of Genetics and Cell Biology, Vita-Salute San Raffaele University, Milan, Italy

Roles: Investigation

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Moreno Zamai

3Unit of Microscopy and Dynamic Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

Roles: Investigation, Visualization, Methodology

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ORCID record for Moreno Zamai

Valeria R Caiolfa

3Unit of Microscopy and Dynamic Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

4Center for Experimental Imaging, IRCCS Ospedale San Raffaele, Milan, Italy

Roles: Investigation, Visualization, Methodology, Investigation, Visualization, Methodology, Investigation, Visualization, Methodology

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Roberto Sitia

2Division of Genetics and Cell Biology, Vita-Salute San Raffaele University, Milan, Italy

Roles: Resources, Supervision, Funding acquisition, Writing—original draft, Writing—review and editing

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ORCID record for Roberto Sitia
For correspondence: sitia.roberto@hsr.it

Anush Bakunts

2Division of Genetics and Cell Biology, Vita-Salute San Raffaele University, Milan, Italy

Roles: Conceptualization, Data curation, Formal analysis, Supervision, Validation, Investigation, Visualization, Writing—original draft, Writing—review and editing

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ORCID record for Anush Bakunts
For correspondence: bakunts.anush@hsr.it

Published 17 June 2024. DOI: 10.26508/lsa.202302562

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It takes more than two for IRE1 activation

Andrea Orsi, Eelco van Anken, Milena Vitale, Moreno Zamai, Valeria R Caiolfa, Roberto Sitia, Anush Bakunts

Life Science Alliance Jun 2024, 7 (9) e202302562; DOI: 10.26508/lsa.202302562

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It takes more than two for IRE1 activation

Andrea Orsi, Eelco van Anken, Milena Vitale, Moreno Zamai, Valeria R Caiolfa, Roberto Sitia, Anush Bakunts

Life Science Alliance Jun 2024, 7 (9) e202302562; DOI: 10.26508/lsa.202302562

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