Table of Contents
Reviews
Recent approaches in computational modelling for controlling pathogen threatsRecent advances and remaining challenges in using computational approaches to model various aspects of pathogen infection and transmission are discussed and reviewed.
Research Articles
The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosisILC1 activation by the oxygen-sensitive transcription factor HIF-1α is detrimental upon acute colitis, but protects against inflammation and fibrosis during chronic colitis.
Calaxin is a key factor for calcium-dependent waveform control in zebrafish spermThis study demonstrates that Calaxin’s calcium-binding activity is necessary for the calcium-induced asymmetric beating of cilia but dispensable to stabilize outer arm dynein.
Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activityThis work shows that dimerization is not sufficient to activate IRE1α and congregation of dimers is needed to trigger cross-phosphorylation and unleash endonuclease activity of this ER stress sensor.
C. elegans LIN-66 mediates EIF-3/eIF3-dependent protein translation via a cold-shock domainC. elegans LIN-66 and its cold-shock domain are required for the specialized activity of the translation initiation factor, EIF-3.G/eIF3g, in the cholinergic motor neurons to regulate locomotion.
The type of DNA damage response after decitabine treatment depends on the level of DNMT activityChromatin-centred proteomics study in stem cells with different DNMT expression levels and activities reveals that decitabine invokes different DNA damage responses depending on the amount of the induced DNA-DNMT crosslinks.
Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD modelsC9orf72 mutations cause multiple mitochondrial disruptions, but only genetically boosting antioxidant expression rescued motor deficits in vivo, supporting a pathogenic connection. Genetic or pharmacological activation of the Keap1/Nrf2 pathway ameliorated pathological phenotypes in Drosophila models and patient-derived iNeurons.
p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleusp53 down-regulates nuclear phosphatidic acid levels to avoid the aberrant accumulation and modification of histone H3.1 during the G1/S phase, in which p53-mediated induction of a specific gene is the initial step.
Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in miceThis study shows that the schizophrenia risk gene NRG1 controls the development of callosal connections and implicates NRG1 signaling in the regulation of GAP43, a key protein for axonal growth.
Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domainThis study reports a cryo-EM structure of a small non-coding RNA transporter, hSIDT1, and delineates the role of lipid in the conformational dynamics of the lipid binding domain of hSIDT1.
Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosolMitochondrial double-stranded RNA is a new signaling molecule that, likely under stress conditions, is exported to induce a type 1 interferon response, thus mimicking a viral response. This export pathway is detected in a subset of lung cancer cell lines.
Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiationSTAT3 and c-SKI repress SMAD3 to induce cDC differentiation.
Roles of Tubulin Concentration during Prometaphase and Ran-GTP during Anaphase of Caenorhabditis elegans MeiosisTubulin dimers concentrate within an ER spindle envelope because cytoplasmic organelles outside the envelope occupy significant volume.
HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizuresBlocking epidermal growth factor receptor signaling after seizures prevents the induction of reactive neural stem cells and preserves neurogenesis in the hippocampus of mice.
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptorsTransmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signalling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations.
FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretionThe ubiquitin-like modifier FAT10 down-regulates the antiviral type-I IFN response not only by targeting OTUB1 but also by degrading the E3 TRIM21 and by inhibiting its activation upon IAV infection.
Distinct groups of autoantigens as drivers of ocular adnexal MALT lymphoma pathogenesisB-cell self-stimulation and local autoimmune reactions are instrumental in the pathogenesis of a substantial fraction of ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphomas.
Cellular zinc status alters chromatin accessibility and binding of p53 to DNAATAC-seq and transcription factor enrichment analysis reveal that perturbations in labile Zn2+ alter chromatin accessibility and enrichment of transcription factor motifs in regions of open chromatin.
ER procollagen storage defect without coupled unfolded protein response drives precocious arthritisThe molecular basis of a collagenopathy is evaluated in an expandable human cartilage model of disease. The pathologic Gly1170Ser substitution causes an ER storage phenotype without inducing the unfolded protein response. This cartilage model could accelerate screening for potential therapies.
Substrate diversity of NSUN enzymes and links of 5-methylcytosine to mRNA translation and turnoverThis study emphasises the emerging diversity of both, m5C writers and readers, affecting mRNA function and provides multiple new leads for future epitranscriptomic research.
Dual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIXThe mitochondrial phosphatase PPTC7 was previously found to suppress mitophagy, but the underlying mechanisms were unclear. Here, the authors show that PPTC7 dynamically localizes to the outer mitochondrial membrane to promote the turnover of the mitophagy receptors BNIP3 and NIX.
Patterning in stratified epithelia depends on cell–cell adhesionCell–cell adhesion regulates multicellular patterning in stratified epithelia, with starvation-induced adherens junctions forming high/low cell density areas, affecting differentiation and proliferation via Yes-associated protein modulation, highlighting epithelial cells’ self-organizing properties.
Global huntingtin knockout in adult mice leads to fatal neurodegeneration that spares the pancreasRecent reports on the consequences of global HTT knock-out have discrepant findings. We confirm here that early loss of HTT leads to subcortical calcification, which is preceded by induction of circulating neurofilament light chain levels, but find no pancreatitis.
Resources
A broken network of susceptibility genes in the monocytes of Crohn’s disease patientsThis study presents a network of genes related to inflammatory bowel disease in the monocytes of the human intestinal tract. In contrast, the network status is broken in Crohn's disease patients, providing insight into the mechanism of susceptibility genes and etiology.
Corrections
- Correction: Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing
Transcriptomic analysis of dengue-infected patients reveals altered immune response pathways, transcript diversity, and splicing efficiency, underscoring potential therapeutic targets for treatment.
Correction: Apolipoprotein E intersects with amyloid-β within neuronsApolipoprotein E4, the most important genetic risk factor for Alzheimer's disease, is shown to internalize into neurons and intersect with amyloid-β in endosomes-autophagosomes of neurites and modulate intraneuronal amyloid-β-42.
- Correction: A consensus molecular subtypes classification strategy for clinical colorectal cancer tissues
This work presents a novel consensus molecular subtype (CMS) classifier for colorectal cancer (CRC), optimized for RNA-sequencing data stemming from degraded RNA of clinical formalin-fixed paraffin-embedded (FFPE) tissue samples (the CMSFFPE classifier).
