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Research Article
Transparent Process
Open Access

Glycolic acid and D-lactate—putative products of DJ-1—restore neurodegeneration in FUS - and SOD1-ALS

Arun Pal, Dajana Grossmann, Hannes Glaß, Vitaly Zimyanin, René Günther, Marica Catinozzi, Tobias M Boeckers, View ORCID ProfileJared Sterneckert, View ORCID ProfileErik Storkebaum, Susanne Petri, Florian Wegner, Stephan W Grill, Francisco Pan-Montojo, View ORCID ProfileAndreas Hermann  Correspondence email
Arun Pal
1Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany
2Dresden High Magnetic Field Laboratory (HLD-EMFL), Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
  • Find this author on Google Scholar
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Dajana Grossmann
3Translational Neurodegeneration Section “Albrecht Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany
Roles: Resources, Data curation, Formal analysis, Visualization, Writing—review and editing
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Hannes Glaß
3Translational Neurodegeneration Section “Albrecht Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany
Roles: Resources, Data curation, Software, Formal analysis, Visualization, Writing—review and editing
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Vitaly Zimyanin
1Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany
4Department of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, USA
5Center for Membrane and Cell Physiology, University of Virginia, School of Medicine, Charlottesville, VA, USA
Roles: Data curation, Formal analysis, Writing—review and editing
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René Günther
1Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany
6Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Dresden, Germany
Roles: Resources, Data curation, Formal analysis, Writing—review and editing
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Marica Catinozzi
9Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands
Roles: Data curation, Formal analysis, Writing—review and editing
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Tobias M Boeckers
7Institute for Anatomy and Cell Biology, Ulm University, as well as Deutsches Zentrum für Neurodegenerative Erkrankungen, Ulm, Germany
Roles: Resources, Writing—review and editing
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Jared Sterneckert
8Center for Regenerative Therapies Dresden, Technische Universität Dresden as well as Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany
Roles: Resources, Writing—review and editing
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  • ORCID record for Jared Sterneckert
Erik Storkebaum
9Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands
Roles: Resources, Data curation, Writing—review and editing
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  • ORCID record for Erik Storkebaum
Susanne Petri
10Department of Neurology, Hannover Medical School, Hannover, Germany
Roles: Resources, Data curation, Writing—review and editing
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Florian Wegner
10Department of Neurology, Hannover Medical School, Hannover, Germany
Roles: Resources, Data curation, Writing—review and editing
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Stephan W Grill
11Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
12Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany
Roles: Resources, Methodology, Writing—review and editing
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Francisco Pan-Montojo
13Department of Psychiatrie and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
Roles: Conceptualization, Resources, Writing—review and editing
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Andreas Hermann
3Translational Neurodegeneration Section “Albrecht Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany
14Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock/Greifswald, Rostock, Germany
15Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany
Roles: Conceptualization, Resources, Supervision, Funding acquisition, Writing—original draft, Project administration, Writing—review and editing
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  • ORCID record for Andreas Hermann
  • For correspondence: Andreas.Hermann{at}med.uni-rostock.de
Published 17 May 2024. DOI: 10.26508/lsa.202302535
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Article Information

vol. 7 no. 8 e202302535
DOI 
https://doi.org/10.26508/lsa.202302535
PubMed 
38760174

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received December 15, 2023
  • Revision received May 5, 2024
  • Accepted May 7, 2024
  • Published online May 17, 2024.

Copyright & Usage 
© 2024 Pal et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Arun Pal1,2, Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  2. Dajana Grossmann3, Resources, Data curation, Formal analysis, Visualization, Writing—review and editing,
  3. Hannes Glaß3, Resources, Data curation, Software, Formal analysis, Visualization, Writing—review and editing,
  4. Vitaly Zimyanin1,4,5, Data curation, Formal analysis, Writing—review and editing,
  5. René Günther1,6, Resources, Data curation, Formal analysis, Writing—review and editing,
  6. Marica Catinozzi9, Data curation, Formal analysis, Writing—review and editing,
  7. Tobias M Boeckers7, Resources, Writing—review and editing,
  8. Jared Sterneckert8, Resources, Writing—review and editing,
  9. Erik Storkebaum9, Resources, Data curation, Writing—review and editing,
  10. Susanne Petri10, Resources, Data curation, Writing—review and editing,
  11. Florian Wegner10, Resources, Data curation, Writing—review and editing,
  12. Stephan W Grill11,12, Resources, Methodology, Writing—review and editing,
  13. Francisco Pan-Montojo13, Conceptualization, Resources, Writing—review and editing and
  14. Andreas Hermann3,14,15⇑, Conceptualization, Resources, Supervision, Funding acquisition, Writing—original draft, Project administration, Writing—review and editing
  1. 1Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany
  2. 2Dresden High Magnetic Field Laboratory (HLD-EMFL), Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
  3. 3Translational Neurodegeneration Section “Albrecht Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany
  4. 4Department of Molecular Physiology and Biological Physics, University of Virginia, School of Medicine, Charlottesville, VA, USA
  5. 5Center for Membrane and Cell Physiology, University of Virginia, School of Medicine, Charlottesville, VA, USA
  6. 6Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Dresden, Germany
  7. 7Institute for Anatomy and Cell Biology, Ulm University, as well as Deutsches Zentrum für Neurodegenerative Erkrankungen, Ulm, Germany
  8. 8Center for Regenerative Therapies Dresden, Technische Universität Dresden as well as Medical Faculty Carl Gustav Carus of TU Dresden, Dresden, Germany
  9. 9Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands
  10. 10Department of Neurology, Hannover Medical School, Hannover, Germany
  11. 11Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
  12. 12Cluster of Excellence Physics of Life, Technische Universität Dresden, Dresden, Germany
  13. 13Department of Psychiatrie and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany
  14. 14Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock/Greifswald, Rostock, Germany
  15. 15Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany
  1. Correspondence: Andreas.Hermann{at}med.uni-rostock.de
  • Francisco Pan-Montojo’s present address is Neurological Clinic am Sorpesee, Sundern-Langscheid, Germany

View Full Text

Funding

  • Hermann und Lilly Schilling-Stiftung für medizinische Forschung im Stifterverband

    A Hermann
  • ERC Consolidator

    ERC-2017-COG 770244
    E Storkebaum
  • Radala Foundation, “Stichting ALS Nederland”, AFM-Telethon, ARSLA, the “Prinses Beatrix Spierfonds”

    W.OR22-03
    E Storkebaum
  • Muscular Dystrophy Association

    946876
    E Storkebaum
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GA and DL restore neurodegeneration in ALS
Arun Pal, Dajana Grossmann, Hannes Glaß, Vitaly Zimyanin, René Günther, Marica Catinozzi, Tobias M Boeckers, Jared Sterneckert, Erik Storkebaum, Susanne Petri, Florian Wegner, Stephan W Grill, Francisco Pan-Montojo, Andreas Hermann
Life Science Alliance May 2024, 7 (8) e202302535; DOI: 10.26508/lsa.202302535

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GA and DL restore neurodegeneration in ALS
Arun Pal, Dajana Grossmann, Hannes Glaß, Vitaly Zimyanin, René Günther, Marica Catinozzi, Tobias M Boeckers, Jared Sterneckert, Erik Storkebaum, Susanne Petri, Florian Wegner, Stephan W Grill, Francisco Pan-Montojo, Andreas Hermann
Life Science Alliance May 2024, 7 (8) e202302535; DOI: 10.26508/lsa.202302535
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Volume 7, No. 8
August 2024
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