Table of Contents
Research Articles
Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson’sThe study highlights the potential of GW4064 and T3 in ameliorating PD as the combination of ligands shows promising effects in reducing ER stress, maintaining mitochondrial activity, and protecting dopaminergic neurons in the MPTP mouse model of PD.
Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolismFrataxin depletion triggers reactive microglia with increase glucose catabolism. Butyrate treatment reinstates immunometabolic balance, potentially offering neuroprotection.
Autocrine VEGF drives neural stem cell proximity to the adult hippocampus vascular nicheAutocrine VEGF signaling is necessary to maintain adult neural stem and progenitor cell proximity to blood vessels in the adult hippocampus and promotes their motility or adhesion.
lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiationThe long non-coding RNA LINC00941 regulates skin differentiation through recruitment of the epigenetic regulator complex NuRD.
Porphyrin overdrive rewires cancer cell metabolismCancer cells exhibit a metabolic phenotype termed “porphyrin overdrive,” characterized by dysregulated heme metabolic pathways for intermediate accumulation. This rewiring is cancer-essential and cancer-specific. Targeting this vulnerability with a “bait-and-kill” strategy shows promise in eradicating malignant cells.
Lineage-specific changes in mitochondrial properties during neural stem cell differentiationDuring SVZ-derived NSC differentiation, Mfn1/2 levels increase, whereas DRP1 levels significantly decrease. Alterations in mitochondrial morphology and bioenergetics are lineage-specific.
Renal antiporter ClC-5 regulates collagen I/IV through the β-catenin pathway and lysosomal degradationThis study describes how ClC-5, the genetic cause of a rare renal pathology, regulates collagen transcription and degradation, providing a better understanding of disease progression to renal fibrosis.
VDR restores the expression of PINK1 and BNIP3 in TECs of streptozotocin-induced diabetic miceVDR protects against fibrosis and defective mitophagy in diabetic mice by regulating mitophagy-related proteins PINK1 and BNIP3.
Molecular mechanism for recognition of the cargo adapter Rab6GTP by the dynein adapter BicD2We present a structural model for recognition of a key modulator of protein secretion, Rab6GTP, by the dynein adapter BicD2, which provides new insights into the trafficking of secretory vesicles.
Trim66’s paternal deficiency causes intrauterine overgrowthTRIM66 is a PHD-Bromo–containing protein primarily expressed in spermatids. Here, we report a paternal effect phenotype whereby homozygous Trim66-mutant males sired progeny overweight at birth.
The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblastsThe interaction between SEPT9 and EPLIN represents an important link between the septin and the actin cytoskeleton, influencing cell adhesion, motility, and migration.
GDF15 controls primary cilia morphology and function thereby affecting progenitor proliferationGDF15/GFRAL ciliary signalling affects cilia morphology, function and proliferation of progenitors contacting the lateral ventricle from late development onwards.
Mitochondrial translation failure represses cholesterol gene expression via Pyk2-Gsk3β-Srebp2 axisThis study reveals Pyk2/Gsk3β axis activation by mitochondrial translation inhibition suppresses cholesterol gene expression via Srebp2 degradation, offering a novel approach to leukoencephalopathy.
The immune and microbial homeostasis determines the Candida–mast cells cross-talk in celiac diseaseThis study shows that the restoration of immune and microbial homeostasis promotes a beneficial Candida albicans–MC cross-talk attenuating the intestinal pathology in celiac disease.
Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivoThis study developed the first GEMM for NUT carcinoma to syntenically recapitulate the t(15;19) chromosome translocation in humans, serving as a critical preclinical model for the disease.
Human T-cell activation with Toxoplasma gondii antigens loaded in maltodextrin nanoparticlesIn this study, we investigated the human immune profile of T-cell subsets activated by a novel maltodextrin nanoparticle conjugated to Toxoplasma gondii antigen.
Timing of TORC1 inhibition dictates Pol III involvement in Caenorhabditis elegans longevityInhibiting RNA Polymerase III engages TOR signalling to control development and improves C. elegans late-life health and longevity.
Inflammatory risk contributes to post-COVID endothelial dysfunction through anti-ACKR1 autoantibodyWe study the prevalence and impact of autoantibodies on vascular dysfunction in healthy COVID-19 survivors, revealing elevated anti-ACKR1 autoantibodies associating with systemic cytokines and endothelial dysfunction. Plasma IgG enhances cellular cytotoxicity, suggesting therapeutic avenues to mitigate vascular autoantibody reactivity post-infection.
Modulating mycobacterial envelope integrity for antibiotic synergy with benzothiazolesThis study explores benzothiazoles targeting a novel mycobacterial vulnerability, resulting in increased mycobacterial cell envelope permeability and enhanced antibiotic activity.
Ribosome rescue factor PELOTA modulates translation start site choice for C/EBPα protein isoformsAlternative translation initiation on a single mRNA can generate distinct protein isoforms. This work finds that the ribosome rescue factor, PELOTA, influences start site choice on the developmental transcription factor, C/EBPα.
Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1Neutrophils, key cells in tuberculosis, reach the lungs as two distinct subsets playing opposite roles in inflammation: either exacerbating via IL-1b or dampening via PD-L1.
Methods
Combining sophisticated fast FLIM, confocal microscopy, and STED nanoscopy for live-cell imaging of tunneling nanotubesHere, we proposed an innovative advanced light imaging to reveal the dynamics of tunneling nanotubes (TNTs) that are now considered as a long- and short-distance route for cell-to-cell communication.
Resources
iMPAQT reveals that adequate mitohormesis from TFAM overexpression leads to life extension in miceOverexpressing TFAM leads to smaller, leaner mice with extended lifespans. The iMPAQT analysis revealed changes in mitochondrial protein expression and characteristic metabolic shifts indicative of mitohormesis as an adaptive strategy in skeletal muscle.
Systems genetics analysis of human body fat distribution genes identifies adipocyte processesUsing Bayesian network analysis, we modeled gene-gene interactions and predicted novel regulators of adipose tissue fat storage. We show that five novel genes affect adipogenesis or mitochondrial function in human fat cells.
REMEMProt: a resource of membrane-enriched proteome profiles, their disease associations, and biomarker statusA resource of experimental specific membrane-enriched mass spectrometry–derived proteome.
