Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

Ling Yin; Xiaoding Hu; Guangsheng Pei; Mengfan Tang; You Zhou; Huimin Zhang; Min Huang; Siting Li; Jie Zhang; Citu Citu; Zhongming Zhao; Bisrat G Debeb; Xu Feng; Junjie Chen

doi:10.26508/lsa.202302353

Research Article

Open Access

Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

View ORCID ProfileLing Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, View ORCID ProfileZhongming Zhao, Bisrat G Debeb, View ORCID ProfileXu Feng Correspondence email, View ORCID ProfileJunjie Chen Correspondence email

Ling Yin

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation, writing—original draft, review and editing, validation, investigation, writing—original draft, review and editing, validation, investigation, writing—original draft, review and editing

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ling Yin

Xiaoding Hu

2Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

3Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Guangsheng Pei

4Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA

5Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA

Roles: data curation, formal analysis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mengfan Tang

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

You Zhou

6Department of Pediatrics Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Huimin Zhang

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Min Huang

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Siting Li

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jie Zhang

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: validation, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Citu Citu

4Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA

5Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA

Roles: resources, data curation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Zhongming Zhao

4Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA

5Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA

Roles: resources, data curation, formal analysis

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Zhongming Zhao

Bisrat G Debeb

2Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

3Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: supervision, investigation

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xu Feng

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

7Pancreas Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China

8Pancreas Institute, Nanjing Medical University, Nanjing, China

Roles: conceptualization, data curation, formal analysis, validation, investigation, visualization, writing—original draft

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Xu Feng
For correspondence: fengxu@njmu.edu.cn

Junjie Chen

1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roles: conceptualization, supervision, funding acquisition, writing—original draft and

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Junjie Chen
For correspondence: JChen8@mdanderson.org

Published 5 February 2024. DOI: 10.26508/lsa.202302353

Article
Figures & Data
Info
Metrics
Reviewer Comments
PDF

You are using an old browser, click here to download PDF

PDF Container

PreviousNext

Download PDF

Email Article

Thank you for your interest in spreading the word on Life Science Alliance.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

Message Subject (Your Name) has sent you a message from Life Science Alliance

Message Body (Your Name) thought you would like to see the Life Science Alliance web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Citation Tools

Responses to radiotherapy

Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen

Life Science Alliance Feb 2024, 7 (4) e202302353; DOI: 10.26508/lsa.202302353

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Responses to radiotherapy

Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen

Life Science Alliance Feb 2024, 7 (4) e202302353; DOI: 10.26508/lsa.202302353

Share This Article:

Tweet Widget

In this Issue

Volume 7, No. 4

April 2024

Table of Contents
Cover (PDF)
About the Cover
Masthead (PDF)

Jump to section

Article
Figures & Data
Info
Metrics
Reviewer Comments
PDF

Subjects

Cancer

No related articles found.

Cited By...

No citing articles found.

Google Scholar

Main menu

User menu

Search

Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

Citation Manager Formats

In this Issue

Subjects

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Content

For Authors

Other Services

More Information