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Research Article
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Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy

View ORCID ProfileLing Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, View ORCID ProfileZhongming Zhao, Bisrat G Debeb, View ORCID ProfileXu Feng  Correspondence email, View ORCID ProfileJunjie Chen  Correspondence email
Ling Yin
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation, writing—original draft, review and editing, validation, investigation, writing—original draft, review and editing, validation, investigation, writing—original draft, review and editing
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  • ORCID record for Ling Yin
Xiaoding Hu
2Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
3Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation
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Guangsheng Pei
4Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA
5Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA
Roles: data curation, formal analysis
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Mengfan Tang
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation
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You Zhou
6Department of Pediatrics Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation
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Huimin Zhang
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation
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Min Huang
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation
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Siting Li
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation
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Jie Zhang
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: validation, investigation
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Citu Citu
4Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA
5Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA
Roles: resources, data curation
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Zhongming Zhao
4Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA
5Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA
Roles: resources, data curation, formal analysis
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Bisrat G Debeb
2Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
3Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: supervision, investigation
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Xu Feng
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
7Pancreas Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
8Pancreas Institute, Nanjing Medical University, Nanjing, China
Roles: conceptualization, data curation, formal analysis, validation, investigation, visualization, writing—original draft
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  • For correspondence: fengxu@njmu.edu.cn
Junjie Chen
1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Roles: conceptualization, supervision, funding acquisition, writing—original draft and
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  • For correspondence: JChen8@mdanderson.org
Published 5 February 2024. DOI: 10.26508/lsa.202302353
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Article Information

vol. 7 no. 4 e202302353
DOI 
https://doi.org/10.26508/lsa.202302353
PubMed 
38316463

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received September 2, 2023
  • Revision received January 21, 2024
  • Accepted January 22, 2024
  • Published online February 5, 2024.

Copyright & Usage 
© 2024 Yin et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Ling Yin1,*, validation, investigation, writing—original draft, review and editing, validation, investigation, writing—original draft, review and editing, validation, investigation, writing—original draft, review and editing,
  2. Xiaoding Hu2,3,*, validation, investigation,
  3. Guangsheng Pei4,5, data curation, formal analysis,
  4. Mengfan Tang1, validation, investigation,
  5. You Zhou6, validation, investigation,
  6. Huimin Zhang1, validation, investigation,
  7. Min Huang1, validation, investigation,
  8. Siting Li1, validation, investigation,
  9. Jie Zhang1, validation, investigation,
  10. Citu Citu4,5, resources, data curation,
  11. Zhongming Zhao4,5, resources, data curation, formal analysis,
  12. Bisrat G Debeb2,3, supervision, investigation,
  13. Xu Feng1,7,8⇑, conceptualization, data curation, formal analysis, validation, investigation, visualization, writing—original draft and
  14. Junjie Chen1⇑, conceptualization, supervision, funding acquisition, writing—original draft and
  1. 1Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  2. 2Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  3. 3Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  4. 4Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA
  5. 5Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA
  6. 6Department of Pediatrics Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  7. 7Pancreas Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
  8. 8Pancreas Institute, Nanjing Medical University, Nanjing, China
  1. Correspondence: JChen8{at}mdanderson.org
  2. fengxu{at}njmu.edu.cn
  1. ↵* Ling Yin and Xiaoding Hu contributed equally to this work

  • Guangsheng Pei’s present address is Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, TX, USA

  • Mengfan Tang’s present address is Department of Immunology, School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China

View Full Text

Funding

  • Cancer Prevention and Research Institute of Texas (CPRIT)

    RP160667, RP180813
    J Chen
  • HHS | NIH | National Cancer Institute (NCI)

    CA210929, CA216911, CA216437, P01 CA193124, CA274234, CA275712
    J Chen
  • Cancer Prevention and Research Institute of Texas (CPRIT)

    RP180734
    Z Zhao
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Responses to radiotherapy
Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen
Life Science Alliance Feb 2024, 7 (4) e202302353; DOI: 10.26508/lsa.202302353

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Responses to radiotherapy
Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen
Life Science Alliance Feb 2024, 7 (4) e202302353; DOI: 10.26508/lsa.202302353
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Volume 7, No. 4
April 2024
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