Reduced myeloid commitment and increased uptake by macrophages of stem cell–derived HPS2 neutrophils

Steven DS Webbers; Cathelijn EM Aarts; Bart Klein; Dané Koops; Judy Geissler; Anton TJ Tool; Robin van Bruggen; Emile van den Akker; Taco W Kuijpers

doi:10.26508/lsa.202302263

Research Article

Open Access

Reduced myeloid commitment and increased uptake by macrophages of stem cell–derived HPS2 neutrophils

View ORCID ProfileSteven DS Webbers Correspondence email, Cathelijn EM Aarts, Bart Klein, View ORCID ProfileDané Koops, View ORCID ProfileJudy Geissler, Anton TJ Tool, Robin van Bruggen, View ORCID ProfileEmile van den Akker, View ORCID ProfileTaco W Kuijpers Correspondence email

Steven DS Webbers

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

3Department of Pediatric Immunology, Rheumatology & Infectious Diseases, Emma Children’s Hospital, AUMC, University of Amsterdam, Amsterdam, Netherlands

Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for Steven DS Webbers
For correspondence: S.webbers@sanquin.nl

Cathelijn EM Aarts

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

Roles: Conceptualization, Formal analysis, Investigation, Methodology, Writing—original draft

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Bart Klein

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

Roles: Investigation, Methodology

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Dané Koops

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

3Department of Pediatric Immunology, Rheumatology & Infectious Diseases, Emma Children’s Hospital, AUMC, University of Amsterdam, Amsterdam, Netherlands

Roles: Formal analysis, Investigation, Methodology

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ORCID record for Dané Koops

Judy Geissler

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

Roles: Investigation, Methodology

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ORCID record for Judy Geissler

Anton TJ Tool

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

Roles: Conceptualization, Investigation, Methodology

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Robin van Bruggen

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

Roles: Conceptualization, Data curation, Supervision, Methodology

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Emile van den Akker

2Department of Hematopoiesis, Sanquin Research Amsterdam, Amsterdam, Netherlands

Roles: Conceptualization, Data curation, Supervision, Methodology

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ORCID record for Emile van den Akker

Taco W Kuijpers

1Department of Molecular Hematology, Sanquin Research, Amsterdam University Medical Center (AUMC), University of Amsterdam, Amsterdam, Netherlands

3Department of Pediatric Immunology, Rheumatology & Infectious Diseases, Emma Children’s Hospital, AUMC, University of Amsterdam, Amsterdam, Netherlands

Roles: Conceptualization, Data curation, Supervision, Funding acquisition, Validation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for Taco W Kuijpers
For correspondence: t.w.kuijpers@amsterdamumc.nl

Published 18 January 2024. DOI: 10.26508/lsa.202302263

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iPSC HPS2 model explains patient neutropenia

Steven DS Webbers, Cathelijn EM Aarts, Bart Klein, Dané Koops, Judy Geissler, Anton TJ Tool, Robin van Bruggen, Emile van den Akker, Taco W Kuijpers

Life Science Alliance Jan 2024, 7 (4) e202302263; DOI: 10.26508/lsa.202302263

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iPSC HPS2 model explains patient neutropenia

Steven DS Webbers, Cathelijn EM Aarts, Bart Klein, Dané Koops, Judy Geissler, Anton TJ Tool, Robin van Bruggen, Emile van den Akker, Taco W Kuijpers

Life Science Alliance Jan 2024, 7 (4) e202302263; DOI: 10.26508/lsa.202302263

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