A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+ leak but activates SERCA2a Ca2+ uptake

Jörg W Wegener; Gyuzel Y Mitronova; Lina ElShareif; Christine Quentin; Vladimir Belov; Tatiana Pochechueva; Gerd Hasenfuss; Lutz Ackermann; Stephan E Lehnart

doi:10.26508/lsa.202302278

Research Article

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A dual-targeted drug inhibits cardiac ryanodine receptor Ca²⁺ leak but activates SERCA2a Ca²⁺ uptake

View ORCID ProfileJörg W Wegener Correspondence email, View ORCID ProfileGyuzel Y Mitronova, View ORCID ProfileLina ElShareif, View ORCID ProfileChristine Quentin, Vladimir Belov, View ORCID ProfileTatiana Pochechueva, View ORCID ProfileGerd Hasenfuss, Lutz Ackermann, View ORCID ProfileStephan E Lehnart Correspondence email

Jörg W Wegener

1Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany

4DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany

Roles: Conceptualization, Formal analysis, Validation, Investigation, Visualization, Writing—original draft

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ORCID record for Jörg W Wegener
For correspondence: joerg.wegener@med.uni-goettingen.de

Gyuzel Y Mitronova

2Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany

4DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany

Roles: Formal analysis, Investigation, Writing—review and editing

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ORCID record for Gyuzel Y Mitronova

Lina ElShareif

1Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany

Roles: Formal analysis, Investigation

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ORCID record for Lina ElShareif

Christine Quentin

2Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany

Roles: Formal analysis, Investigation

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ORCID record for Christine Quentin

Vladimir Belov

2Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany

Roles: Formal analysis, Supervision

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Tatiana Pochechueva

1Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany

4DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany

Roles: Investigation, Cell Culture

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ORCID record for Tatiana Pochechueva

Gerd Hasenfuss

1Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany

4DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany

Roles: Resources, Project administration

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Lutz Ackermann

3Georg-August University of Göttingen, Institute of Organic and Biomolecular Chemistry, Göttingen, Germany

4DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany

Roles: Resources

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Stephan E Lehnart

1Department of Cardiology and Pulmonology, Heart Research Center Göttingen, University Medical Center of Göttingen (UMG), Göttingen, Germany

4DZHK (German Centre for Cardiovascular Research), Partner Site Göttingen, Göttingen, Germany

Roles: Conceptualization, Data curation, Funding acquisition, Writing—review and editing

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ORCID record for Stephan E Lehnart
For correspondence: slehnart@med.uni-goettingen.de

Published 27 November 2023. DOI: 10.26508/lsa.202302278

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A multi-acting compound on Ca²⁺ cycling

Jörg W Wegener, Gyuzel Y Mitronova, Lina ElShareif, Christine Quentin, Vladimir Belov, Tatiana Pochechueva, Gerd Hasenfuss, Lutz Ackermann, Stephan E Lehnart

Life Science Alliance Nov 2023, 7 (2) e202302278; DOI: 10.26508/lsa.202302278

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A multi-acting compound on Ca²⁺ cycling

Jörg W Wegener, Gyuzel Y Mitronova, Lina ElShareif, Christine Quentin, Vladimir Belov, Tatiana Pochechueva, Gerd Hasenfuss, Lutz Ackermann, Stephan E Lehnart

Life Science Alliance Nov 2023, 7 (2) e202302278; DOI: 10.26508/lsa.202302278

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