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Research Article
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Proteomic-based stratification of intermediate-risk prostate cancer patients

View ORCID ProfileQing Zhong, Rui Sun, View ORCID ProfileAdel T Aref, Zainab Noor, Asim Anees, Yi Zhu, View ORCID ProfileNatasha Lucas, Rebecca C Poulos, Mengge Lyu, Tiansheng Zhu, View ORCID ProfileGuo-Bo Chen, Yingrui Wang, Xuan Ding, View ORCID ProfileDorothea Rutishauser, Niels J Rupp, Jan H Rueschoff, View ORCID ProfileCédric Poyet, Thomas Hermanns, Christian Fankhauser, View ORCID ProfileMaría Rodríguez Martínez, Wenguang Shao, Marija Buljan, Janis Frederick Neumann, View ORCID ProfileAndreas Beyer, View ORCID ProfilePeter G Hains, View ORCID ProfileRoger R Reddel, Phillip J Robinson, View ORCID ProfileRuedi Aebersold  Correspondence email, View ORCID ProfileTiannan Guo  Correspondence email, View ORCID ProfilePeter J Wild  Correspondence email
Qing Zhong
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Conceptualization, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
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Rui Sun
2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
Roles: Validation, Visualization, Writing—review and editing
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Adel T Aref
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Validation
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  • ORCID record for Adel T Aref
Zainab Noor
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Validation, Visualization
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Asim Anees
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Validation, Visualization
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Yi Zhu
2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
Roles: Conceptualization
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Natasha Lucas
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Formal analysis
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  • ORCID record for Natasha Lucas
Rebecca C Poulos
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Data curation
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Mengge Lyu
2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
Roles: Data curation
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Tiansheng Zhu
2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
Roles: Data curation
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Guo-Bo Chen
4Urology & Nephrology Center, Department of Urology, Clinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China
Roles: Data curation
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  • ORCID record for Guo-Bo Chen
Yingrui Wang
2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
Roles: Data curation
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Xuan Ding
2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
Roles: Data curation
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Dorothea Rutishauser
5Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland
Roles: Formal analysis
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  • ORCID record for Dorothea Rutishauser
Niels J Rupp
5Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland
Roles: Data curation
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Jan H Rueschoff
5Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland
Roles: Data curation
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Cédric Poyet
6Department of Urology, University Hospital Zürich, Zürich, Switzerland
Roles: Conceptualization, Data curation
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Thomas Hermanns
6Department of Urology, University Hospital Zürich, Zürich, Switzerland
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Christian Fankhauser
6Department of Urology, University Hospital Zürich, Zürich, Switzerland
7Department of Urology, Cantonal Hospital Lucerne, Lucerne, Switzerland
Roles: Data curation
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María Rodríguez Martínez
8IBM Zürich Research Laboratory, Zürich, Switzerland
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  • ORCID record for María Rodríguez Martínez
Wenguang Shao
9State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
Roles: Conceptualization
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Marija Buljan
10Empa - Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
11Swiss Institute of Bioinformatics, Lausanne, Switzerland
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Janis Frederick Neumann
12CECAD, University of Cologne, Cologne, Germany
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Andreas Beyer
12CECAD, University of Cologne, Cologne, Germany
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  • ORCID record for Andreas Beyer
Peter G Hains
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Formal analysis
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Roger R Reddel
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Conceptualization
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Phillip J Robinson
1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
Roles: Conceptualization
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Ruedi Aebersold
13Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland
14Faculty of Science, University of Zürich, Zürich, Switzerland
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  • For correspondence: aebersold@imsb.biol.ethz.ch
Tiannan Guo
2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
Roles: Conceptualization, Formal analysis, Supervision, Investigation, Methodology, Writing—original draft
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  • For correspondence: guotiannan@westlake.edu.cn
Peter J Wild
15Goethe University Frankfurt, Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany
16Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany
Roles: Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Investigation, Methodology, Writing—original draft, Project administration
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  • For correspondence: peter.wild@ukffm.de
Published 4 December 2023. DOI: 10.26508/lsa.202302146
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Article Information

vol. 7 no. 2 e202302146
DOI 
https://doi.org/10.26508/lsa.202302146
PubMed 
38052461

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 9, 2023
  • Revision received November 22, 2023
  • Accepted November 23, 2023
  • Published online December 4, 2023.

Copyright & Usage 
© 2023 Zhong et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Qing Zhong1,*, Conceptualization, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing,
  2. Rui Sun2,3,*, Validation, Visualization, Writing—review and editing,
  3. Adel T Aref1,*, Validation,
  4. Zainab Noor1,*, Validation, Visualization,
  5. Asim Anees1,*, Validation, Visualization,
  6. Yi Zhu2,3, Conceptualization,
  7. Natasha Lucas1, Formal analysis,
  8. Rebecca C Poulos1, Data curation,
  9. Mengge Lyu2,3, Data curation,
  10. Tiansheng Zhu2,3, Data curation,
  11. Guo-Bo Chen4, Data curation,
  12. Yingrui Wang2,3, Data curation,
  13. Xuan Ding2,3, Data curation,
  14. Dorothea Rutishauser5, Formal analysis,
  15. Niels J Rupp5, Data curation,
  16. Jan H Rueschoff5, Data curation,
  17. Cédric Poyet6, Conceptualization, Data curation,
  18. Thomas Hermanns6, Data curation,
  19. Christian Fankhauser6,7, Data curation,
  20. María Rodríguez Martínez8, Formal analysis,
  21. Wenguang Shao9, Conceptualization,
  22. Marija Buljan10,11, Formal analysis,
  23. Janis Frederick Neumann12, Data curation,
  24. Andreas Beyer12, Conceptualization,
  25. Peter G Hains1, Formal analysis,
  26. Roger R Reddel1, Conceptualization,
  27. Phillip J Robinson1, Conceptualization,
  28. Ruedi Aebersold13,14, Conceptualization, Supervision, Funding acquisition, Investigation, Methodology, Project administration⇑,
  29. Tiannan Guo2,3, Conceptualization, Formal analysis, Supervision, Investigation, Methodology, Writing—original draft⇑ and
  30. Peter J Wild15,16, Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Investigation, Methodology, Writing—original draft, Project administration⇑
  1. 1ProCan, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia
  2. 2iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China
  3. 3Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China
  4. 4Urology & Nephrology Center, Department of Urology, Clinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China
  5. 5Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland
  6. 6Department of Urology, University Hospital Zürich, Zürich, Switzerland
  7. 7Department of Urology, Cantonal Hospital Lucerne, Lucerne, Switzerland
  8. 8IBM Zürich Research Laboratory, Zürich, Switzerland
  9. 9State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
  10. 10Empa - Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  11. 11Swiss Institute of Bioinformatics, Lausanne, Switzerland
  12. 12CECAD, University of Cologne, Cologne, Germany
  13. 13Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland
  14. 14Faculty of Science, University of Zürich, Zürich, Switzerland
  15. 15Goethe University Frankfurt, Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany
  16. 16Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany
  1. Correspondence: aebersold{at}imsb.biol.ethz.ch
  2. guotiannan{at}westlake.edu.cn
  3. peter.wild{at}ukffm.de
  1. ↵* Qing Zhong, Rui Sun, Adel T Aref, Zainab Noor, and Asim Anees contributed equally to this work

View Full Text

Funding

  • EC | Horizon 2020 Framework Programme (H2020)

    668858 - PrECISE
    PJ Wild
  • EC | Horizon 2020 Framework Programme (H2020)

    826121 - iPC
    R Aebersold
  • Bundesministerium für Bildung und Forschung (BMBF)

    01KD2213C - PROSurvival
    PJ Wild
  • National Natural Science Foundation of China

    81972492
    T Guo
  • SNSF SystemsX.ch fellowship

    TPdF 2013/135
    M Buljan
  • National Natural Science Foundation of China

    62102248, 32271493
    W Shao
  • National Key Research and Development Program of China

    2022YFC3401600
    W Shao
  • NHMRC Fellowships

    GNT1138536, GNT1137064
    RC Poulos, PJ Robinson
  • National Breast Cancer Foundation

    IIRS-18-164
  • European Commission’s Horizon 2020 Program

    H2020-SC1-DTH-2018-1
  • National Health and Medical Research Council

    GNT1170739
  • Cancer Council NSW

    IG 18-01
  • NSW Ministry of Health

    CMP-01
  • Cancer Institute New South Wales

    2017/TPG001, REG171150
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Proteomic-based stratification of prostate cancer patients
Qing Zhong, Rui Sun, Adel T Aref, Zainab Noor, Asim Anees, Yi Zhu, Natasha Lucas, Rebecca C Poulos, Mengge Lyu, Tiansheng Zhu, Guo-Bo Chen, Yingrui Wang, Xuan Ding, Dorothea Rutishauser, Niels J Rupp, Jan H Rueschoff, Cédric Poyet, Thomas Hermanns, Christian Fankhauser, María Rodríguez Martínez, Wenguang Shao, Marija Buljan, Janis Frederick Neumann, Andreas Beyer, Peter G Hains, Roger R Reddel, Phillip J Robinson, Ruedi Aebersold, Tiannan Guo, Peter J Wild
Life Science Alliance Dec 2023, 7 (2) e202302146; DOI: 10.26508/lsa.202302146

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Proteomic-based stratification of prostate cancer patients
Qing Zhong, Rui Sun, Adel T Aref, Zainab Noor, Asim Anees, Yi Zhu, Natasha Lucas, Rebecca C Poulos, Mengge Lyu, Tiansheng Zhu, Guo-Bo Chen, Yingrui Wang, Xuan Ding, Dorothea Rutishauser, Niels J Rupp, Jan H Rueschoff, Cédric Poyet, Thomas Hermanns, Christian Fankhauser, María Rodríguez Martínez, Wenguang Shao, Marija Buljan, Janis Frederick Neumann, Andreas Beyer, Peter G Hains, Roger R Reddel, Phillip J Robinson, Ruedi Aebersold, Tiannan Guo, Peter J Wild
Life Science Alliance Dec 2023, 7 (2) e202302146; DOI: 10.26508/lsa.202302146
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