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Research Article
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Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9–mediated genome engineering in HAP1 cells mimicking cancer profiles

View ORCID ProfileKeyi Geng, View ORCID ProfileLara G Merino, View ORCID ProfileRaül G Veiga, View ORCID ProfileChristian Sommerauer, View ORCID ProfileJanine Epperlein, View ORCID ProfileEva K Brinkman, View ORCID ProfileClaudia Kutter  Correspondence email
Keyi Geng
Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
Roles: Conceptualization, Data curation, Software, Formal analysis, Supervision, Validation, Investigation, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Keyi Geng
Lara G Merino
Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Lara G Merino
Raül G Veiga
Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
Roles: Data curation, Software, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Raül G Veiga
Christian Sommerauer
Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
Roles: Data curation, Formal analysis, Writing—original draft, Writing—review and editing
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  • ORCID record for Christian Sommerauer
Janine Epperlein
Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
Roles: Validation, Investigation, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Janine Epperlein
Eva K Brinkman
Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
Roles: Data curation, Formal analysis, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Eva K Brinkman
Claudia Kutter
Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
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  • ORCID record for Claudia Kutter
  • For correspondence: claudia.kutter{at}ki.se
Published 20 November 2023. DOI: 10.26508/lsa.202302128
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Article Information

vol. 7 no. 2 e202302128
DOI 
https://doi.org/10.26508/lsa.202302128
PubMed 
37984988

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 2, 2023
  • Revision received November 6, 2023
  • Accepted November 7, 2023
  • Published online November 20, 2023.

Copyright & Usage 
© 2023 Geng et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Keyi Geng, Conceptualization, Data curation, Software, Formal analysis, Supervision, Validation, Investigation, Methodology, Writing—original draft, Writing—review and editing,
  2. Lara G Merino, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  3. Raül G Veiga, Data curation, Software, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  4. Christian Sommerauer, Data curation, Formal analysis, Writing—original draft, Writing—review and editing,
  5. Janine Epperlein, Validation, Investigation, Methodology, Writing—original draft, Writing—review and editing,
  6. Eva K Brinkman, Data curation, Formal analysis, Methodology, Writing—original draft, Writing—review and editing and
  7. Claudia Kutter, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing⇑
  1. Department of Microbiology, Tumor, and Cell Biology, Science for Life Laboratory, Karolinska Institute, Solna, Sweden
  1. Correspondence: claudia.kutter{at}ki.se
View Full Text

Funding

  • Chinese Scholarship Council

    201700260271
    K Geng, C Kutter
  • EMBO Postdoctoral Fellowship

    EMBO-ALTF-1046-2019
    EK Brinkman
  • Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)

    KAW 2016.0174
    C Kutter
  • Ruth och Richard Julins Stiftelse (Ruth and Richard Julin Foundation)

    2017-00358, 2018-00328, 2020-00294
    C Kutter
  • SFO SciLifeLab fellowship

    SFO_004
    C Kutter
  • Karolinska Institutet - KID

    2018-00904
    C Kutter
  • Vetenskapsrådet (VR)

    2019-05165
    C Kutter
  • Lillian Sagen & Curt Ericsson Research Foundation

    2021-00427
    C Kutter
  • Gösta Milton’s Research Foundation

    2021-00527
    C Kutter
  • Cancerfonden (Swedish Cancer Society)

    22 2246 Pj
    C Kutter
  • Uppsala University | Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX)

    2017/7- 261, SNIC 2020/16-223, SNIC 2020/15-292, SNIC 2021/22-899, SNIC 2021/23-652, SNIC 2022/22-10
    K Geng, C Kutter
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Common cancer signatures upon Δ10q23.31
Keyi Geng, Lara G Merino, Raül G Veiga, Christian Sommerauer, Janine Epperlein, Eva K Brinkman, Claudia Kutter
Life Science Alliance Nov 2023, 7 (2) e202302128; DOI: 10.26508/lsa.202302128

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Common cancer signatures upon Δ10q23.31
Keyi Geng, Lara G Merino, Raül G Veiga, Christian Sommerauer, Janine Epperlein, Eva K Brinkman, Claudia Kutter
Life Science Alliance Nov 2023, 7 (2) e202302128; DOI: 10.26508/lsa.202302128
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Volume 7, No. 2
February 2024
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