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Research Article
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Open Access

TLR3 activation mediates partial epithelial-to-mesenchymal transition in human keratinocytes

View ORCID ProfileAndrea M Schneider, View ORCID ProfileRobert P Feehan, View ORCID ProfileMackenzie L Sennett, Carson A Wills, View ORCID ProfileCharlotte Garner, Zhaoyuan Cong, Elizabeth M Billingsley, Alexandra F Flamm, View ORCID ProfileLisa M Shantz, View ORCID ProfileAmanda M Nelson  Correspondence email
Andrea M Schneider
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Andrea M Schneider
Robert P Feehan
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Robert P Feehan
Mackenzie L Sennett
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Formal analysis, Investigation, Writing—original draft, Writing—review and editing, Formal analysis, Investigation, Writing—original draft, Writing—review and editing
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  • ORCID record for Mackenzie L Sennett
Carson A Wills
2Department of Pediatrics, Penn State College of Medicine, Hershey, PA, USA
Roles: Formal analysis, Investigation, Writing—review and editing
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Charlotte Garner
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Formal analysis, Investigation, Writing—review and editing
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  • ORCID record for Charlotte Garner
Zhaoyuan Cong
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Formal analysis, Investigation, Writing—review and editing
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Elizabeth M Billingsley
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Resources, Investigation, Writing—review and editing
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Alexandra F Flamm
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Resources, Formal analysis, Writing—review and editing
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Lisa M Shantz
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
3Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA
Roles: Formal analysis, Methodology, Writing—original draft, Writing—review and editing
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  • ORCID record for Lisa M Shantz
Amanda M Nelson
1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Methodology, Writing—original draft, Project administration, Writing—review and editing
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  • For correspondence: anelson@pennstatehealth.psu.edu
Published 30 September 2024. DOI: 10.26508/lsa.202402777
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Article Information

vol. 7 no. 12 e202402777
DOI 
https://doi.org/10.26508/lsa.202402777
PubMed 
39348939

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received April 18, 2024
  • Revision received September 23, 2024
  • Accepted September 23, 2024
  • Published online September 30, 2024.

Copyright & Usage 
© 2024 Schneider et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Andrea M Schneider1, Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  2. Robert P Feehan1, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  3. Mackenzie L Sennett1, Formal analysis, Investigation, Writing—original draft, Writing—review and editing, Formal analysis, Investigation, Writing—original draft, Writing—review and editing,
  4. Carson A Wills2, Formal analysis, Investigation, Writing—review and editing,
  5. Charlotte Garner1, Formal analysis, Investigation, Writing—review and editing,
  6. Zhaoyuan Cong1, Formal analysis, Investigation, Writing—review and editing,
  7. Elizabeth M Billingsley1, Resources, Investigation, Writing—review and editing,
  8. Alexandra F Flamm1, Resources, Formal analysis, Writing—review and editing,
  9. Lisa M Shantz1,3, Formal analysis, Methodology, Writing—original draft, Writing—review and editing and
  10. Amanda M Nelson1⇑, Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Methodology, Writing—original draft, Project administration, Writing—review and editing
  1. 1Department of Dermatology, Penn State Health Hershey Medical Center, Hershey, PA, USA
  2. 2Department of Pediatrics, Penn State College of Medicine, Hershey, PA, USA
  3. 3Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA
  1. Correspondence: anelson{at}pennstatehealth.psu.edu
  • Carson A Wills’s present address is Department of Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA

  • Alexandra F Flamm’s present address is Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA

View Full Text

Funding

  • HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

    K01AR069721
    AM Nelson
  • HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)

    F30ES030260
    AM Schneider
  • American Skin Association (ASA)

    No grant number
    AM Schneider
  • Dermatology Department Research Endowment, Penn State College of Medicine

    AM Nelson
  • The Jake Gittlen Laboratories for Cancer Research at Penn State College of Medicine

    AM Schneider, AM Nelson
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TLR3 activation induces partial EMT
Andrea M Schneider, Robert P Feehan, Mackenzie L Sennett, Carson A Wills, Charlotte Garner, Zhaoyuan Cong, Elizabeth M Billingsley, Alexandra F Flamm, Lisa M Shantz, Amanda M Nelson
Life Science Alliance Sep 2024, 7 (12) e202402777; DOI: 10.26508/lsa.202402777

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TLR3 activation induces partial EMT
Andrea M Schneider, Robert P Feehan, Mackenzie L Sennett, Carson A Wills, Charlotte Garner, Zhaoyuan Cong, Elizabeth M Billingsley, Alexandra F Flamm, Lisa M Shantz, Amanda M Nelson
Life Science Alliance Sep 2024, 7 (12) e202402777; DOI: 10.26508/lsa.202402777
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Volume 7, No. 12
December 2024
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