Research Article
Open Access
Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab
View ORCID ProfileNobuhisa Iwata Correspondence email, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, View ORCID ProfileNaoko Kamano, Ryo Fujioka, Risa Takamura, View ORCID ProfileNaoto Watamura, Naomasa Kakiya, Naomi Mihira, View ORCID ProfileTakahiro Morito, View ORCID ProfileKeiro Shirotani, David MA Mann, View ORCID ProfileAndrew C Robinson, View ORCID ProfileShoko Hashimoto, View ORCID ProfileHiroki Sasaguri, View ORCID ProfileTakashi Saito, Makoto Higuchi, View ORCID ProfileTakaomi C Saido Correspondence email
Nobuhisa Iwata
1Department of Genome-Based Drug Discovery and Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Conceptualization, Resources, Data curation, Software, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
Satoshi Tsubuki
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Software, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft
Misaki Sekiguchi
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Investigation, Methodology
Kaori Watanabe-Iwata
1Department of Genome-Based Drug Discovery and Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Roles: Resources, Data curation, Formal analysis, Investigation, Methodology
Yukio Matsuba
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Investigation, Methodology
Naoko Kamano
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Investigation, Methodology
Ryo Fujioka
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Investigation, Methodology
Risa Takamura
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Data curation, Formal analysis, Investigation, Methodology
Naoto Watamura
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology
Naomasa Kakiya
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Data curation, Validation, Investigation, Methodology
Naomi Mihira
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Investigation, Methodology
Takahiro Morito
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Formal analysis, Investigation, Methodology
Keiro Shirotani
1Department of Genome-Based Drug Discovery and Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Roles: Resources, Data curation, Formal analysis, Investigation, Methodology
David MA Mann
3Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, UK
Roles: Resources, Data curation, Investigation, Methodology
Andrew C Robinson
3Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, UK
Roles: Resources, Data curation, Investigation, Methodology
Shoko Hashimoto
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Resources, Data curation, Investigation, Methodology
Hiroki Sasaguri
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Data curation, Formal analysis, Methodology
Takashi Saito
4Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
5Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
Roles: Conceptualization, Resources, Data curation, Formal analysis, Investigation, Methodology, Writing—original draft
Makoto Higuchi
6Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, Japan
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Writing—original draft
Takaomi C Saido
2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
Roles: Conceptualization, Funding acquisition, Validation, Writing—original draft, Writing—review and editing
Published 30 September 2024. DOI: 10.26508/lsa.202402650
Metabolic resistance of Aβ3pE-42, an epitope of donanemab
Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David MA Mann, Andrew C Robinson, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Makoto Higuchi, Takaomi C Saido
Life Science Alliance Sep 2024, 7 (12) e202402650; DOI: 10.26508/lsa.202402650
Metabolic resistance of Aβ3pE-42, an epitope of donanemab
Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David MA Mann, Andrew C Robinson, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Makoto Higuchi, Takaomi C Saido
Life Science Alliance Sep 2024, 7 (12) e202402650; DOI: 10.26508/lsa.202402650
In this Issue
Volume 7, No. 12
December 2024
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