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Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab

Nobuhisa Iwata  Correspondence email, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David MA Mann, Andrew C Robinson, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Makoto Higuchi, Takaomi C Saido  Correspondence email
Published 30 September 2024. DOI: 10.26508/lsa.202402650

Article Information

vol. 7 no. 12 e202402650
DOI 
https://doi.org/10.26508/lsa.202402650
PubMed 
39348937
Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received February 8, 2024
  • Revision received September 6, 2024
  • Accepted September 6, 2024
  • Published online September 30, 2024.
Copyright & Usage 
© 2024 Iwata et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Nobuhisa Iwata1,2⇑, Conceptualization, Resources, Data curation, Software, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing,
  2. Satoshi Tsubuki2, Resources, Data curation, Software, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft,
  3. Misaki Sekiguchi2, Resources, Data curation, Investigation, Methodology,
  4. Kaori Watanabe-Iwata1, Resources, Data curation, Formal analysis, Investigation, Methodology,
  5. Yukio Matsuba2, Resources, Data curation, Investigation, Methodology,
  6. Naoko Kamano2, Resources, Data curation, Investigation, Methodology,
  7. Ryo Fujioka2, Resources, Data curation, Investigation, Methodology,
  8. Risa Takamura2, Data curation, Formal analysis, Investigation, Methodology,
  9. Naoto Watamura2, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology,
  10. Naomasa Kakiya2, Data curation, Validation, Investigation, Methodology,
  11. Naomi Mihira2, Resources, Data curation, Investigation, Methodology,
  12. Takahiro Morito2, Resources, Data curation, Formal analysis, Investigation, Methodology,
  13. Keiro Shirotani1, Resources, Data curation, Formal analysis, Investigation, Methodology,
  14. David MA Mann3, Resources, Data curation, Investigation, Methodology,
  15. Andrew C Robinson3, Resources, Data curation, Investigation, Methodology,
  16. Shoko Hashimoto2, Resources, Data curation, Investigation, Methodology,
  17. Hiroki Sasaguri2, Data curation, Formal analysis, Methodology,
  18. Takashi Saito4,5, Conceptualization, Resources, Data curation, Formal analysis, Investigation, Methodology, Writing—original draft,
  19. Makoto Higuchi6, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Investigation, Visualization, Methodology, Writing—original draft and
  20. Takaomi C Saido2⇑, Conceptualization, Funding acquisition, Validation, Writing—original draft, Writing—review and editing
  1. 1Department of Genome-Based Drug Discovery and Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
  2. 2Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan
  3. 3Division of Neuroscience, Faculty of Biology, Medicine and Health, School of Biological Sciences, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Salford Royal Hospital, Salford, UK
  4. 4Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  5. 5Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan
  6. 6Department of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, Japan
  1. Correspondence: iwata-n{at}nagasaki-u.ac.jp
  2. takaomi.saido{at}riken.jp
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Funding

  • Japan Agency for Medical Research and Development (AMED)

    JP20dm0207001
    TC Saido

  • Japan Society for the Promotion of Science (JSPS) KAKENHI

    JP18K07402
    H Sasaguri

  • Japan Society for the Promotion of Science (JSPS) KAKENHI

    JP17025046, JP18023037, JP20023031
    N Iwata
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Metabolic resistance of Aβ3pE-42, an epitope of donanemab
Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, David MA Mann, Andrew C Robinson, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Makoto Higuchi, Takaomi C Saido
Life Science Alliance Sep 2024, 7 (12) e202402650; DOI: 10.26508/lsa.202402650
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Volume 7, No. 12
December 2024
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