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Research Article
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Open Access

Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides

View ORCID ProfileRubika Balendra, View ORCID ProfileIgor Ruiz de los Mozos, Hana M Odeh, View ORCID ProfileIdoia Glaria, View ORCID ProfileCarmelo Milioto, Katherine M Wilson, Agnieszka M Ule, Martina Hallegger, Laura Masino, Stephen Martin, Rickie Patani, View ORCID ProfileJames Shorter, View ORCID ProfileJernej Ule  Correspondence email, View ORCID ProfileAdrian M Isaacs  Correspondence email
Rubika Balendra
1UK Dementia Research Institute at UCL, London, UK
2Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
Roles: Conceptualization, Resources, Data curation, Software, Formal analysis, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
  • Find this author on Google Scholar
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  • ORCID record for Rubika Balendra
Igor Ruiz de los Mozos
3The Francis Crick Institute, London, UK
4Department of Personalized Medicine, NASERTIC, Government of Navarra, Pamplona, Spain
5Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK
Roles: Resources, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
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  • ORCID record for Igor Ruiz de los Mozos
Hana M Odeh
6Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Roles: Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
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Idoia Glaria
1UK Dementia Research Institute at UCL, London, UK
2Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
7Research Support Service, Institute of Agrobiotechnology, CSIC-Government of Navarra, Mutilva, Spain
Roles: Investigation, Writing—review and editing
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  • ORCID record for Idoia Glaria
Carmelo Milioto
1UK Dementia Research Institute at UCL, London, UK
2Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
Roles: Investigation, Writing—review and editing
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  • ORCID record for Carmelo Milioto
Katherine M Wilson
1UK Dementia Research Institute at UCL, London, UK
2Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
Roles: Investigation, Writing—review and editing
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Agnieszka M Ule
5Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK
Roles: Investigation, Methodology, Writing—review and editing
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Martina Hallegger
3The Francis Crick Institute, London, UK
Roles: Investigation, Methodology, Writing—review and editing
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Laura Masino
8Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK
Roles: Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
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Stephen Martin
8Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK
Roles: Supervision, Writing—review and editing
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Rickie Patani
3The Francis Crick Institute, London, UK
5Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK
Roles: Supervision, Writing—review and editing
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James Shorter
6Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Roles: Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
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Jernej Ule
3The Francis Crick Institute, London, UK
5Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK
9UK Dementia Research Institute at King’s College London, Maurice Wohl Clinical Neuroscience Institute, London, UK
Roles: Conceptualization, Resources, Data curation, Software, Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
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  • For correspondence: jernej.ule@kcl.ac.uk
Adrian M Isaacs
1UK Dementia Research Institute at UCL, London, UK
2Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
Roles: Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing
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  • ORCID record for Adrian M Isaacs
  • For correspondence: a.isaacs@ucl.ac.uk
Published 12 July 2023. DOI: 10.26508/lsa.202201824
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Article Information

vol. 6 no. 9 e202201824
DOI 
https://doi.org/10.26508/lsa.202201824
PubMed 
37438085

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received November 11, 2022
  • Revision received June 25, 2023
  • Accepted June 26, 2023
  • Published online July 12, 2023.

Copyright & Usage 
© 2023 Balendra et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Rubika Balendra1,2,*, Conceptualization, Resources, Data curation, Software, Formal analysis, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing,
  2. Igor Ruiz de los Mozos3,4,5,*, Resources, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing,
  3. Hana M Odeh6, Data curation, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing,
  4. Idoia Glaria1,2,7, Investigation, Writing—review and editing,
  5. Carmelo Milioto1,2, Investigation, Writing—review and editing,
  6. Katherine M Wilson1,2, Investigation, Writing—review and editing,
  7. Agnieszka M Ule5, Investigation, Methodology, Writing—review and editing,
  8. Martina Hallegger3, Investigation, Methodology, Writing—review and editing,
  9. Laura Masino8, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  10. Stephen Martin8, Supervision, Writing—review and editing,
  11. Rickie Patani3,5, Supervision, Writing—review and editing,
  12. James Shorter6, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  13. Jernej Ule3,5,9, Conceptualization, Resources, Data curation, Software, Formal analysis, Supervision, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing⇑ and
  14. Adrian M Isaacs1,2, Conceptualization, Resources, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing⇑
  1. 1UK Dementia Research Institute at UCL, London, UK
  2. 2Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
  3. 3The Francis Crick Institute, London, UK
  4. 4Department of Personalized Medicine, NASERTIC, Government of Navarra, Pamplona, Spain
  5. 5Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK
  6. 6Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
  7. 7Research Support Service, Institute of Agrobiotechnology, CSIC-Government of Navarra, Mutilva, Spain
  8. 8Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK
  9. 9UK Dementia Research Institute at King’s College London, Maurice Wohl Clinical Neuroscience Institute, London, UK
  1. Correspondence: a.isaacs{at}ucl.ac.uk
  2. jernej.ule{at}kcl.ac.uk
  1. ↵* Rubika Balendra and Igor Ruiz de los Mozos contributed equally to this work

View Full Text

Funding

  • National Institute for Health and Care Research (NIHR)

    R Balendra
  • Wellcome Trust (WT)

    107196/Z/14/Z
    R Balendra
  • Academy of Medical Sciences (The Academy of Medical Sciences)

    SGL027\1022
    R Balendra
  • Motor Neurone Disease Association (MNDA)

    ARUK-PG2016A-6, ARUK-EXT2019A-002
    AM Isaacs
  • Alzheimer’s Research UK (ARUK)

    ARUK-PG2016A-6, ARUK-EXT2019A-002
    AM Isaacs
  • EC | Horizon 2020 Framework Programme (H2020)

    648716—C9ND
    AM Isaacs
  • UK Dementia Research Institute (UK DRI)

    AM Isaacs
  • AstraZeneca HealthCare Foundation (AZHCF)

    HM Odeh
  • Alzheimer’s Association (AA)

    HM Odeh
  • ALS Association (ALSA)

    J Shorter
  • Target ALS (Target ALS Foundation)

    J Shorter
  • Association for Frontotemporal Degeneration (AFTD)

    J Shorter
  • JHU | SOM, JHU | Robert Packard Center for ALS Research, Johns Hopkins University (Robert Packard Center)

    J Shorter
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Transcriptome-wide poly(PR)-RNA binding
Rubika Balendra, Igor Ruiz de los Mozos, Hana M Odeh, Idoia Glaria, Carmelo Milioto, Katherine M Wilson, Agnieszka M Ule, Martina Hallegger, Laura Masino, Stephen Martin, Rickie Patani, James Shorter, Jernej Ule, Adrian M Isaacs
Life Science Alliance Jul 2023, 6 (9) e202201824; DOI: 10.26508/lsa.202201824

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Transcriptome-wide poly(PR)-RNA binding
Rubika Balendra, Igor Ruiz de los Mozos, Hana M Odeh, Idoia Glaria, Carmelo Milioto, Katherine M Wilson, Agnieszka M Ule, Martina Hallegger, Laura Masino, Stephen Martin, Rickie Patani, James Shorter, Jernej Ule, Adrian M Isaacs
Life Science Alliance Jul 2023, 6 (9) e202201824; DOI: 10.26508/lsa.202201824
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Volume 6, No. 9
September 2023
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