SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing

Vikrant K Bhosle; Joel MJ Tan; Taoyingnan Li; Rong Hua; Hyunwoo Kwon; Zhubing Li; Sajedabanu Patel; Marc Tessier-Lavigne; Lisa A Robinson; Peter K Kim; John H Brumell

doi:10.26508/lsa.202301964

Research Article

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SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing

View ORCID ProfileVikrant K Bhosle, View ORCID ProfileJoel MJ Tan, Taoyingnan Li, Rong Hua, View ORCID ProfileHyunwoo Kwon, View ORCID ProfileZhubing Li, Sajedabanu Patel, Marc Tessier-Lavigne, Lisa A Robinson Correspondence email, View ORCID ProfilePeter K Kim Correspondence email, View ORCID ProfileJohn H Brumell Correspondence email

Vikrant K Bhosle

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

Roles: Formal analysis, Investigation, Methodology, Writing—original draft, Writing—review and editing

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ORCID record for Vikrant K Bhosle

Joel MJ Tan

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

Roles: Formal analysis, Investigation, Methodology, Writing—original draft

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ORCID record for Joel MJ Tan

Taoyingnan Li

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

2Department of Molecular Genetics, University of Toronto, Toronto, Canada

Roles: Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing

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Rong Hua

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

Roles: Investigation, Methodology

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Hyunwoo Kwon

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

3Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

Roles: Conceptualization, Investigation, Methodology, Writing—original draft

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ORCID record for Hyunwoo Kwon

Zhubing Li

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

Roles: Resources, Methodology

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ORCID record for Zhubing Li

Sajedabanu Patel

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

Roles: Resources

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Marc Tessier-Lavigne

4Laboratory of Brain Development and Repair, Rockefeller University, New York, NY, USA

5Department of Biology, Stanford University, Stanford, CA, USA

Roles: Resources, Writing—original draft

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Lisa A Robinson

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

6Institute of Medical Science, University of Toronto, Toronto, Canada

7Division of Nephrology, The Hospital for Sick Children, Toronto, Canada

8Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Canada

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Methodology, Writing—original draft

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For correspondence: lisa.robinson@sickkids.ca

Peter K Kim

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

9Department of Biochemistry, University of Toronto, Toronto, Canada

Roles: Resources, Supervision, Funding acquisition, Writing—original draft

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ORCID record for Peter K Kim
For correspondence: pkim@sickkids.ca

John H Brumell

1Cell Biology Program, The Hospital for Sick Children, Toronto, Canada

2Department of Molecular Genetics, University of Toronto, Toronto, Canada

6Institute of Medical Science, University of Toronto, Toronto, Canada

10SickKids IBD Centre, Hospital for Sick Children, Toronto, Canada

Roles: Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for John H Brumell
For correspondence: john.brumell@sickkids.ca

Published 13 June 2023. DOI: 10.26508/lsa.202301964

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SLIT2/ROBO1 signaling suppresses mTORC1

Vikrant K Bhosle, Joel MJ Tan, Taoyingnan Li, Rong Hua, Hyunwoo Kwon, Zhubing Li, Sajedabanu Patel, Marc Tessier-Lavigne, Lisa A Robinson, Peter K Kim, John H Brumell

Life Science Alliance Jun 2023, 6 (8) e202301964; DOI: 10.26508/lsa.202301964

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SLIT2/ROBO1 signaling suppresses mTORC1

Vikrant K Bhosle, Joel MJ Tan, Taoyingnan Li, Rong Hua, Hyunwoo Kwon, Zhubing Li, Sajedabanu Patel, Marc Tessier-Lavigne, Lisa A Robinson, Peter K Kim, John H Brumell

Life Science Alliance Jun 2023, 6 (8) e202301964; DOI: 10.26508/lsa.202301964

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