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Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids

View ORCID ProfileVictoria Ptasinski, View ORCID ProfileSusan J Monkley, Karolina Öst, View ORCID ProfileMarkus Tammia, View ORCID ProfileHani N Alsafadi, View ORCID ProfileCatherine Overed-Sayer, Petra Hazon, View ORCID ProfileDarcy E Wagner, View ORCID ProfileLynne A Murray  Correspondence email
Victoria Ptasinski
1Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
2Department of Experimental Medical Sciences, Lung Bioengineering and Regeneration, Lund University, Lund, Sweden
3Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden
4Lund Stem Cell Center, Lund University, Lund, Sweden
Roles: Conceptualization, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing
  • Find this author on Google Scholar
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  • ORCID record for Victoria Ptasinski
Susan J Monkley
5Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
Roles: Formal analysis, Methodology, Writing—review and editing
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  • ORCID record for Susan J Monkley
Karolina Öst
1Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
Roles: Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—review and editing
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Markus Tammia
1Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
Roles: Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing
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  • ORCID record for Markus Tammia
Hani N Alsafadi
2Department of Experimental Medical Sciences, Lung Bioengineering and Regeneration, Lund University, Lund, Sweden
3Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden
4Lund Stem Cell Center, Lund University, Lund, Sweden
Roles: Formal analysis, Visualization, Methodology, Writing—review and editing
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hani N Alsafadi
Catherine Overed-Sayer
6Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Roles: Investigation, Methodology, Writing—review and editing
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  • ORCID record for Catherine Overed-Sayer
Petra Hazon
1Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
Roles: Conceptualization, Supervision, Writing—original draft, Project administration, Writing—review and editing
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Darcy E Wagner
2Department of Experimental Medical Sciences, Lung Bioengineering and Regeneration, Lund University, Lund, Sweden
3Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden
4Lund Stem Cell Center, Lund University, Lund, Sweden
Roles: Conceptualization, Supervision, Funding acquisition, Writing—original draft, Project administration, Writing—review and editing
  • Find this author on Google Scholar
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  • ORCID record for Darcy E Wagner
Lynne A Murray
6Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Roles: Conceptualization, Supervision, Funding acquisition, Writing—original draft, Project administration, Writing—review and editing
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  • For correspondence: lynnemurray@hotmail.com
Published 25 May 2023. DOI: 10.26508/lsa.202201853
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Article Information

vol. 6 no. 8 e202201853
DOI 
https://doi.org/10.26508/lsa.202201853
PubMed 
37230801

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received November 25, 2022
  • Revision received May 9, 2023
  • Accepted May 10, 2023
  • Published online May 25, 2023.

Copyright & Usage 
© 2023 Ptasinski et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Victoria Ptasinski1,2,3,4, Conceptualization, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing,
  2. Susan J Monkley5, Formal analysis, Methodology, Writing—review and editing,
  3. Karolina Öst1, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—review and editing,
  4. Markus Tammia5, Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing,
  5. Hani N Alsafadi2,3,4, Formal analysis, Visualization, Methodology, Writing—review and editing,
  6. Catherine Overed-Sayer6, Investigation, Methodology, Writing—review and editing,
  7. Petra Hazon1, Conceptualization, Supervision, Writing—original draft, Project administration, Writing—review and editing,
  8. Darcy E Wagner2,3,4,*, Conceptualization, Supervision, Funding acquisition, Writing—original draft, Project administration, Writing—review and editing and
  9. Lynne A Murray6,*, Conceptualization, Supervision, Funding acquisition, Writing—original draft, Project administration, Writing—review and editing⇑
  1. 1Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
  2. 2Department of Experimental Medical Sciences, Lung Bioengineering and Regeneration, Lund University, Lund, Sweden
  3. 3Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden
  4. 4Lund Stem Cell Center, Lund University, Lund, Sweden
  5. 5Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
  6. 6Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
  1. Correspondence: lynnemurray{at}hotmail.com
View Full Text

Funding

  • Vetenskapsrådet (VR)

    2018-02352
    DE Wagner
  • Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)

    KAW 2020.0182
    DE Wagner
  • Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)

    DE Wagner
  • Region Skåne

    DE Wagner
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Modeling IPF in iPSC-derived alveolar organoids
Victoria Ptasinski, Susan J Monkley, Karolina Öst, Markus Tammia, Hani N Alsafadi, Catherine Overed-Sayer, Petra Hazon, Darcy E Wagner, Lynne A Murray
Life Science Alliance May 2023, 6 (8) e202201853; DOI: 10.26508/lsa.202201853

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Modeling IPF in iPSC-derived alveolar organoids
Victoria Ptasinski, Susan J Monkley, Karolina Öst, Markus Tammia, Hani N Alsafadi, Catherine Overed-Sayer, Petra Hazon, Darcy E Wagner, Lynne A Murray
Life Science Alliance May 2023, 6 (8) e202201853; DOI: 10.26508/lsa.202201853
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Volume 6, No. 8
August 2023
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