Research Article
Open Access
MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex
View ORCID ProfileMary Rose Branch, Cynthia L Hsu, Kohta Ohnishi, Wen-Chuan Shen, Elian Lee, Jill Meisenhelder, Brett Winborn, Bryce L Sopher, J Paul Taylor, Tony Hunter, View ORCID ProfileAlbert R La Spada Correspondence email
Mary Rose Branch
1Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA
2Department of Neurology, Duke University School of Medicine, Durham, NC, USA
Roles: Conceptualization, Formal analysis, Validation, Investigation, Methodology, Writing—original draft, Writing—review and editing
Cynthia L Hsu
3Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA
Roles: Conceptualization, Formal analysis, Validation, Investigation, Methodology, Writing—original draft, Writing—review and editing
Kohta Ohnishi
3Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA
Roles: Conceptualization, Formal analysis, Validation, Investigation, Methodology, Writing—original draft, Writing—review and editing
Wen-Chuan Shen
1Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA
Roles: Formal analysis, Investigation, Methodology
Elian Lee
3Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA
Roles: Formal analysis, Investigation, Methodology
Jill Meisenhelder
4Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA
Roles: Formal analysis, Validation, Investigation, Methodology
Brett Winborn
5Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
Roles: Formal analysis, Investigation, Methodology
Bryce L Sopher
6Department of Pathology, University of Washington Medical Center, Seattle, WA, USA
Roles: Conceptualization, Formal analysis, Investigation, Methodology
J Paul Taylor
5Department of Cell and Molecular Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA
7Howard Hughes Medical Institute, Chevy Chase, MD, USA
Roles: Data curation, Formal analysis, Supervision, Validation
Tony Hunter
4Molecular and Cellular Biology Laboratory, Salk Institute, La Jolla, CA, USA
Roles: Conceptualization, Formal analysis, Supervision, Validation, Methodology
Albert R La Spada
1Departments of Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine, CA, USA
2Department of Neurology, Duke University School of Medicine, Durham, NC, USA
3Department of Pediatrics, University of California, San Diego; La Jolla, CA, USA
8UCI Institute for Neurotherapeutics, University of California, Irvine, CA, USA
Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Validation, Investigation, Methodology, Writing—original draft, Project administration, Writing—review and editing
Published 23 May 2023. DOI: 10.26508/lsa.202201525
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MAP4K3 amino acid dependent pathway of mTORC1 activation
Mary Rose Branch, Cynthia L Hsu, Kohta Ohnishi, Wen-Chuan Shen, Elian Lee, Jill Meisenhelder, Brett Winborn, Bryce L Sopher, J Paul Taylor, Tony Hunter, Albert R La Spada
Life Science Alliance May 2023, 6 (8) e202201525; DOI: 10.26508/lsa.202201525
MAP4K3 amino acid dependent pathway of mTORC1 activation
Mary Rose Branch, Cynthia L Hsu, Kohta Ohnishi, Wen-Chuan Shen, Elian Lee, Jill Meisenhelder, Brett Winborn, Bryce L Sopher, J Paul Taylor, Tony Hunter, Albert R La Spada
Life Science Alliance May 2023, 6 (8) e202201525; DOI: 10.26508/lsa.202201525
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Volume 6, No. 8
August 2023
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