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The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand

Yoko K Takada, Scott I Simon, View ORCID ProfileYoshikazu Takada  Correspondence email
Yoko K Takada
1Department of Dermatology, UC Davis School of Medicine, Sacramento, CA, USA
Roles: Data curation
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Scott I Simon
1Department of Dermatology, UC Davis School of Medicine, Sacramento, CA, USA
2Department of Biomedical Engineering, UC Davis, Davis, CA, USA
Roles: Resources, Writing—review and editing
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Yoshikazu Takada
1Department of Dermatology, UC Davis School of Medicine, Sacramento, CA, USA
3Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, CA, USA
Roles: Conceptualization, Formal analysis, Funding acquisition, Project administration
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  • ORCID record for Yoshikazu Takada
  • For correspondence: ytakada@ucdavis.edu
Published 25 April 2023. DOI: 10.26508/lsa.202201747
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Integrin binding to CD62P lectin domain
Yoko K Takada, Scott I Simon, Yoshikazu Takada
Life Science Alliance Apr 2023, 6 (7) e202201747; DOI: 10.26508/lsa.202201747

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Integrin binding to CD62P lectin domain
Yoko K Takada, Scott I Simon, Yoshikazu Takada
Life Science Alliance Apr 2023, 6 (7) e202201747; DOI: 10.26508/lsa.202201747
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Volume 6, No. 7
July 2023
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  • FGF2 binds to the allosteric site (site 2) and activates integrin {alpha}IIb{beta}3 and FGF1 binds to site 2 but suppresses integrin activation by FGF2: A potential mechanism of anti-thrombotic action of FGF1
  • FGF2 binds to the allosteric site (site 2) and activates {alpha}v{beta}3 integrin and FGF1 binds to site 2 but suppresses integrin activation by FGF2: a potential mechanism of anti-inflammatory action of FGF1
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