Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis

Liron Birimberg-Schwartz; Wan Ip; Claire Bartlett; Julie Avolio; Annelotte M Vonk; Tarini Gunawardena; Kai Du; Mohsen Esmaeili; Jeffrey M Beekman; Johanna Rommens; Lisa Strug; Christine E Bear; Theo J Moraes; Tanja Gonska

doi:10.26508/lsa.202201857

Research Article

Open Access

Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis

View ORCID ProfileLiron Birimberg-Schwartz, Wan Ip, Claire Bartlett, Julie Avolio, Annelotte M Vonk, View ORCID ProfileTarini Gunawardena, Kai Du, Mohsen Esmaeili, Jeffrey M Beekman, Johanna Rommens, Lisa Strug, Christine E Bear, View ORCID ProfileTheo J Moraes, View ORCID ProfileTanja Gonska Correspondence email

Liron Birimberg-Schwartz

1Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Toronto, Toronto, Canada

2Translational Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Conceptualization, Resources, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for Liron Birimberg-Schwartz

Wan Ip

2Translational Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Conceptualization, Resources, Data curation, Formal analysis, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing

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Claire Bartlett

2Translational Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Resources, Data curation, Formal analysis, Investigation, Methodology, Writing—review and editing

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Julie Avolio

2Translational Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Resources, Data curation, Project administration, Writing—review and editing

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Annelotte M Vonk

3Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands

13Department of Pediatric Pulmonology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherland

Roles: Methodology, Writing—review and editing

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Tarini Gunawardena

4Programme in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Resources, Data curation, Investigation, Writing—review and editing

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ORCID record for Tarini Gunawardena

Kai Du

4Programme in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Data curation, Investigation, Writing—review and editing

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Mohsen Esmaeili

5Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

Roles: Data curation, Investigation, Writing—review and editing

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Jeffrey M Beekman

3Regenerative Medicine Utrecht, University Medical Center, Utrecht University, Utrecht, The Netherlands

13Department of Pediatric Pulmonology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht University, Member of ERN-LUNG, Utrecht, The Netherland

Roles: Methodology, Writing—review and editing

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Johanna Rommens

5Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

6Department of Molecular Genetics, University of Toronto, Toronto, Canada

Roles: Methodology, Writing—review and editing

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Lisa Strug

5Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada

7Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

8Department of Statistical Sciences and Computer Science, University of Toronto, Toronto, Canada

9The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Canada

Roles: Resources, Writing—review and editing

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Christine E Bear

4Programme in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada

10Department of Physiology, University of Toronto, Toronto, Canada

11Department of Biochemistry, University of Toronto, Toronto, Canada

Roles: Resources, Methodology, Writing—review and editing

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Theo J Moraes

2Translational Medicine, The Hospital for Sick Children, Toronto, Canada

12Department of Paediatrics, Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Resources, Methodology, Writing—review and editing

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ORCID record for Theo J Moraes

Tanja Gonska

1Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Toronto, Toronto, Canada

2Translational Medicine, The Hospital for Sick Children, Toronto, Canada

Roles: Conceptualization, Resources, Formal analysis, Supervision, Funding acquisition, Visualization, Methodology, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for Tanja Gonska
For correspondence: Tanja.Gonska@sickkids.ca

Published 5 April 2023. DOI: 10.26508/lsa.202201857

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2D intestinal organoids for CF personalized therapy

Liron Birimberg-Schwartz, Wan Ip, Claire Bartlett, Julie Avolio, Annelotte M Vonk, Tarini Gunawardena, Kai Du, Mohsen Esmaeili, Jeffrey M Beekman, Johanna Rommens, Lisa Strug, Christine E Bear, Theo J Moraes, Tanja Gonska

Life Science Alliance Apr 2023, 6 (6) e202201857; DOI: 10.26508/lsa.202201857

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2D intestinal organoids for CF personalized therapy

Life Science Alliance Apr 2023, 6 (6) e202201857; DOI: 10.26508/lsa.202201857

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