Structure-based design and characterization of Parkin-activating mutations

Michael U Stevens; Nathalie Croteau; Mohamed A Eldeeb; Odetta Antico; Zhi Wei Zeng; Rachel Toth; Thomas M Durcan; Wolfdieter Springer; Edward A Fon; Miratul MK Muqit; Jean-François Trempe

doi:10.26508/lsa.202201419

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Structure-based design and characterization of Parkin-activating mutations

Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, View ORCID ProfileRachel Toth, Thomas M Durcan, View ORCID ProfileWolfdieter Springer, View ORCID ProfileEdward A Fon Correspondence email, View ORCID ProfileMiratul MK Muqit Correspondence email, View ORCID ProfileJean-François Trempe Correspondence email

Michael U Stevens

1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK

Roles: Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing

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Nathalie Croteau

2Department of Pharmacology & Therapeutics, McGill University, Montréal, Canada

3Centre de Recherche en Biologie Structurale, Montpellier, France

Roles: Formal analysis, Investigation, Methodology, Writing—review and editing

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Mohamed A Eldeeb

4McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Canada

Roles: Formal analysis, Investigation, Methodology, Writing—review and editing

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Odetta Antico

1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK

Roles: Data curation, Formal analysis, Methodology

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Zhi Wei Zeng

2Department of Pharmacology & Therapeutics, McGill University, Montréal, Canada

Roles: Investigation, Methodology

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Rachel Toth

1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK

Roles: Resources, Methodology

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ORCID record for Rachel Toth

Thomas M Durcan

4McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Canada

Roles: Conceptualization, Funding acquisition

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Wolfdieter Springer

5Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

6Neuroscience PhD Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA

Roles: Conceptualization, Funding acquisition

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ORCID record for Wolfdieter Springer

Edward A Fon

4McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Canada

Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing Plain Text

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ORCID record for Edward A Fon
For correspondence: ted.fon@mcgill.ca m.muqit@dundee.ac.uk jeanfrancois.trempe@mcgill.ca

Miratul MK Muqit

1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK

Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing

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ORCID record for Miratul MK Muqit
For correspondence: ted.fon@mcgill.ca m.muqit@dundee.ac.uk jeanfrancois.trempe@mcgill.ca

Jean-François Trempe

2Department of Pharmacology & Therapeutics, McGill University, Montréal, Canada

3Centre de Recherche en Biologie Structurale, Montpellier, France

Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for Jean-François Trempe
For correspondence: ted.fon@mcgill.ca m.muqit@dundee.ac.uk jeanfrancois.trempe@mcgill.ca

Published 20 March 2023. DOI: 10.26508/lsa.202201419

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Design of Parkin activating mutations

Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe

Life Science Alliance Mar 2023, 6 (6) e202201419; DOI: 10.26508/lsa.202201419

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Design of Parkin activating mutations

Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe

Life Science Alliance Mar 2023, 6 (6) e202201419; DOI: 10.26508/lsa.202201419

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