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Research Article
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Structure-based design and characterization of Parkin-activating mutations

Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, View ORCID ProfileRachel Toth, Thomas M Durcan, View ORCID ProfileWolfdieter Springer, View ORCID ProfileEdward A Fon  Correspondence email, View ORCID ProfileMiratul MK Muqit  Correspondence email, View ORCID ProfileJean-François Trempe  Correspondence email
Michael U Stevens
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
Roles: Formal analysis, Investigation, Visualization, Methodology, Writing—review and editing
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Nathalie Croteau
2Department of Pharmacology & Therapeutics, McGill University, Montréal, Canada
3Centre de Recherche en Biologie Structurale, Montpellier, France
Roles: Formal analysis, Investigation, Methodology, Writing—review and editing
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Mohamed A Eldeeb
4McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Canada
Roles: Formal analysis, Investigation, Methodology, Writing—review and editing
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Odetta Antico
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
Roles: Data curation, Formal analysis, Methodology
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Zhi Wei Zeng
2Department of Pharmacology & Therapeutics, McGill University, Montréal, Canada
Roles: Investigation, Methodology
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Rachel Toth
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
Roles: Resources, Methodology
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  • ORCID record for Rachel Toth
Thomas M Durcan
4McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Canada
Roles: Conceptualization, Funding acquisition
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Wolfdieter Springer
5Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
6Neuroscience PhD Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA
Roles: Conceptualization, Funding acquisition
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  • ORCID record for Wolfdieter Springer
Edward A Fon
4McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Canada
Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing Plain Text
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  • ORCID record for Edward A Fon
  • For correspondence: ted.fon@mcgill.ca m.muqit@dundee.ac.uk jeanfrancois.trempe@mcgill.ca
Miratul MK Muqit
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee, UK
Roles: Conceptualization, Supervision, Funding acquisition, Project administration, Writing—review and editing
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  • ORCID record for Miratul MK Muqit
  • For correspondence: ted.fon@mcgill.ca m.muqit@dundee.ac.uk jeanfrancois.trempe@mcgill.ca
Jean-François Trempe
2Department of Pharmacology & Therapeutics, McGill University, Montréal, Canada
3Centre de Recherche en Biologie Structurale, Montpellier, France
Roles: Conceptualization, Data curation, Formal analysis, Supervision, Funding acquisition, Investigation, Visualization, Writing—original draft, Project administration, Writing—review and editing
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  • ORCID record for Jean-François Trempe
  • For correspondence: ted.fon@mcgill.ca m.muqit@dundee.ac.uk jeanfrancois.trempe@mcgill.ca
Published 20 March 2023. DOI: 10.26508/lsa.202201419
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Design of Parkin activating mutations
Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe
Life Science Alliance Mar 2023, 6 (6) e202201419; DOI: 10.26508/lsa.202201419

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Design of Parkin activating mutations
Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe
Life Science Alliance Mar 2023, 6 (6) e202201419; DOI: 10.26508/lsa.202201419
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Volume 6, No. 6
June 2023
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