Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss

Yoichiro Iwasa; Miles J Klimara; Hidekane Yoshimura; William D Walls; Ryotaro Omichi; Cody A West; Seiji B Shibata; Paul T Ranum; Richard JH Smith

doi:10.26508/lsa.202201592

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Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss

Yoichiro Iwasa, View ORCID ProfileMiles J Klimara, View ORCID ProfileHidekane Yoshimura, View ORCID ProfileWilliam D Walls, Ryotaro Omichi, Cody A West, Seiji B Shibata, Paul T Ranum, View ORCID ProfileRichard JH Smith Correspondence email

Yoichiro Iwasa

1Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan

Roles: Conceptualization, Formal analysis, Investigation, Methodology, Writing—original draft

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Miles J Klimara

2Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA, USA

Roles: Formal analysis, Methodology, Writing—original draft, Writing—review and editing, Co—first author

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ORCID record for Miles J Klimara

Hidekane Yoshimura

3Department of Otolaryngology – Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Roles: Conceptualization, Investigation

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ORCID record for Hidekane Yoshimura

William D Walls

2Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA, USA

Roles: Formal analysis, Visualization, Writing—review and editing

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ORCID record for William D Walls

Ryotaro Omichi

3Department of Otolaryngology – Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Roles: Conceptualization, Investigation

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Cody A West

2Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA, USA

Roles: Investigation

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Seiji B Shibata

4Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA

Roles: Conceptualization, Writing—review and editing

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Paul T Ranum

5Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA

Roles: Conceptualization, Investigation

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Richard JH Smith

2Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA, USA

Roles: Conceptualization, Formal analysis, Supervision, Funding acquisition, Writing—review and editing

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ORCID record for Richard JH Smith
For correspondence: richard-smith@uiowa.edu

Published 27 December 2022. DOI: 10.26508/lsa.202201592

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Mutation-agnostic RNAi for deafness

Yoichiro Iwasa, Miles J Klimara, Hidekane Yoshimura, William D Walls, Ryotaro Omichi, Cody A West, Seiji B Shibata, Paul T Ranum, Richard JH Smith

Life Science Alliance Dec 2022, 6 (3) e202201592; DOI: 10.26508/lsa.202201592

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Mutation-agnostic RNAi for deafness

Yoichiro Iwasa, Miles J Klimara, Hidekane Yoshimura, William D Walls, Ryotaro Omichi, Cody A West, Seiji B Shibata, Paul T Ranum, Richard JH Smith

Life Science Alliance Dec 2022, 6 (3) e202201592; DOI: 10.26508/lsa.202201592

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