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Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss

Yoichiro Iwasa, Miles J Klimara, Hidekane Yoshimura, William D Walls, Ryotaro Omichi, Cody A West, Seiji B Shibata, Paul T Ranum, Richard JH Smith  Correspondence email
Published 27 December 2022. DOI: 10.26508/lsa.202201592

Article Information

vol. 6 no. 3 e202201592
DOI 
https://doi.org/10.26508/lsa.202201592
PubMed 
36574989
Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received July 6, 2022
  • Revision received December 14, 2022
  • Accepted December 14, 2022
  • Published online December 27, 2022.
Copyright & Usage 
© 2022 Iwasa et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Yoichiro Iwasa1,*, Conceptualization, Formal analysis, Investigation, Methodology, Writing—original draft,
  2. Miles J Klimara2,*, Formal analysis, Methodology, Writing—original draft, Writing—review and editing, Co—first author,
  3. Hidekane Yoshimura3, Conceptualization, Investigation,
  4. William D Walls2, Formal analysis, Visualization, Writing—review and editing,
  5. Ryotaro Omichi3, Conceptualization, Investigation,
  6. Cody A West2, Investigation,
  7. Seiji B Shibata4, Conceptualization, Writing—review and editing,
  8. Paul T Ranum5, Conceptualization, Investigation and
  9. Richard JH Smith2, Conceptualization, Formal analysis, Supervision, Funding acquisition, Writing—review and editing⇑
  1. 1Department of Otorhinolaryngology, Shinshu University School of Medicine, Matsumoto, Japan
  2. 2Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology – Head and Neck Surgery, University of Iowa, Iowa City, IA, USA
  3. 3Department of Otolaryngology – Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  4. 4Department of Otolaryngology Head and Neck Surgery, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA
  5. 5Raymond G. Perelman Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, PA, USA
  1. Correspondence: richard-smith{at}uiowa.edu
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Funding

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    5T32DC000040
    MJ Klimara

  • HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)

    DC002842; DC012049; DC017955
    RJH Smith
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Mutation-agnostic RNAi for deafness
Yoichiro Iwasa, Miles J Klimara, Hidekane Yoshimura, William D Walls, Ryotaro Omichi, Cody A West, Seiji B Shibata, Paul T Ranum, Richard JH Smith
Life Science Alliance Dec 2022, 6 (3) e202201592; DOI: 10.26508/lsa.202201592
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Volume 6, No. 3
March 2023
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