Disease- and sex-specific differences in patients with heart valve disease: a proteome study

Sarah Nordmeyer; Milena Kraus; Matthias Ziehm; Marieluise Kirchner; Marie Schafstedde; Marcus Kelm; Sylvia Niquet; Mariet Mathew Stephen; Istvan Baczko; Christoph Knosalla; Matthieu-P Schapranow; Gunnar Dittmar; Michael Gotthardt; Martin Falcke; Vera Regitz-Zagrosek; Titus Kuehne; Philipp Mertins

doi:10.26508/lsa.202201411

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Disease- and sex-specific differences in patients with heart valve disease: a proteome study

View ORCID ProfileSarah Nordmeyer Correspondence email, View ORCID ProfileMilena Kraus, View ORCID ProfileMatthias Ziehm, View ORCID ProfileMarieluise Kirchner, View ORCID ProfileMarie Schafstedde, Marcus Kelm, Sylvia Niquet, Mariet Mathew Stephen, View ORCID ProfileIstvan Baczko, View ORCID ProfileChristoph Knosalla, View ORCID ProfileMatthieu-P Schapranow, View ORCID ProfileGunnar Dittmar, View ORCID ProfileMichael Gotthardt, View ORCID ProfileMartin Falcke, Vera Regitz-Zagrosek, Titus Kuehne Correspondence email, View ORCID ProfilePhilipp Mertins Correspondence email

Sarah Nordmeyer

1Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Institute for Cardiovascular Computer-Assisted Medicine, Berlin, Germany

2Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Department of Congenital Heart Disease – Pediatric Cardiology, Berlin, Germany

3German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany

Roles: Conceptualization, Data curation, Formal analysis, Validation, Investigation, Visualization, Writing—original draft, Project administration, Writing—review and editing

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ORCID record for Sarah Nordmeyer
For correspondence: snordmeyer@dhzb.de titus.kuehne@dhzb.de philipp.mertins@mdc-berlin.de

Milena Kraus

4Hasso Plattner Institute for Digital Engineering, Digital Health Center, University of Potsdam, Potsdam, Germany

Roles: Conceptualization, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing—original draft, Writing—review and editing

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ORCID record for Milena Kraus

Matthias Ziehm

5Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Proteomics Platform, Berlin, Germany

6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

Roles: Conceptualization, Software, Formal analysis, Validation, Writing—original draft, Writing—review and editing

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ORCID record for Matthias Ziehm

Marieluise Kirchner

5Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Proteomics Platform, Berlin, Germany

6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

Roles: Conceptualization, Formal analysis, Validation, Visualization, Methodology, Writing—original draft, Writing—review and editing

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ORCID record for Marieluise Kirchner

Marie Schafstedde

1Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Institute for Cardiovascular Computer-Assisted Medicine, Berlin, Germany

2Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Department of Congenital Heart Disease – Pediatric Cardiology, Berlin, Germany

3German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany

6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

Roles: Data curation, Investigation, Project administration, Writing—review and editing

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ORCID record for Marie Schafstedde

Marcus Kelm

1Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Institute for Cardiovascular Computer-Assisted Medicine, Berlin, Germany

2Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Department of Congenital Heart Disease – Pediatric Cardiology, Berlin, Germany

6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

Roles: Data curation, Formal analysis, Writing—review and editing

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Sylvia Niquet

5Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Proteomics Platform, Berlin, Germany

6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

Roles: Data curation, Formal analysis, Writing—review and editing

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Mariet Mathew Stephen

4Hasso Plattner Institute for Digital Engineering, Digital Health Center, University of Potsdam, Potsdam, Germany

Roles: Software, Formal analysis, Writing—review and editing

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Istvan Baczko

7Department of Pharmacology and Pharmacotherapy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary

Roles: Data curation, Investigation, Writing—review and editing

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ORCID record for Istvan Baczko

Christoph Knosalla

3German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany

8Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart, Department of Cardiothoracic and Vascular Surgery, Berlin, Germany

9Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Roles: Data curation, Funding acquisition, Investigation, Writing—review and editing

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ORCID record for Christoph Knosalla

Matthieu-P Schapranow

4Hasso Plattner Institute for Digital Engineering, Digital Health Center, University of Potsdam, Potsdam, Germany

Roles: Resources, Supervision, Funding acquisition, Writing—review and editing

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Gunnar Dittmar

10Proteomics of Cellular Signaling, Luxembourg Institute of Health, Strassen, Luxembourg

Roles: Conceptualization, Funding acquisition, Writing—review and editing

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ORCID record for Gunnar Dittmar

Michael Gotthardt

3German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany

9Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

11Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Neuromuscular and Cardiovascular Cell Biology, Berlin, Germany

Roles: Supervision, Validation, Writing—review and editing

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ORCID record for Michael Gotthardt

Martin Falcke

12Max Delbrück Center for Molecular Medicine, Mathematical Cell Physiology, Berlin, Germany

Roles: Resources, Funding acquisition, Writing—review and editing

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ORCID record for Martin Falcke

Vera Regitz-Zagrosek

9Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

13Department of Cardiology, University Hospital Zürich, University of Zürich, Zürich, Switzerland

Roles: Conceptualization, Supervision, Funding acquisition, Writing—review and editing

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Titus Kuehne

1Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Institute for Cardiovascular Computer-Assisted Medicine, Berlin, Germany

2Deutsches Herzzentrum der Charité – Medical Heart Center of Charité and German Heart Institute Berlin, Department of Congenital Heart Disease – Pediatric Cardiology, Berlin, Germany

3German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany

9Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing

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For correspondence: snordmeyer@dhzb.de titus.kuehne@dhzb.de philipp.mertins@mdc-berlin.de

Philipp Mertins

3German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany

5Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Proteomics Platform, Berlin, Germany

6Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

Roles: Conceptualization, Resources, Supervision, Funding acquisition, Project administration, Writing—review and editing

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ORCID record for Philipp Mertins
For correspondence: snordmeyer@dhzb.de titus.kuehne@dhzb.de philipp.mertins@mdc-berlin.de

Published 10 January 2023. DOI: 10.26508/lsa.202201411

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Proteome profiling in heart valve disease

Sarah Nordmeyer, Milena Kraus, Matthias Ziehm, Marieluise Kirchner, Marie Schafstedde, Marcus Kelm, Sylvia Niquet, Mariet Mathew Stephen, Istvan Baczko, Christoph Knosalla, Matthieu-P Schapranow, Gunnar Dittmar, Michael Gotthardt, Martin Falcke, Vera Regitz-Zagrosek, Titus Kuehne, Philipp Mertins

Life Science Alliance Jan 2023, 6 (3) e202201411; DOI: 10.26508/lsa.202201411

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Proteome profiling in heart valve disease

Life Science Alliance Jan 2023, 6 (3) e202201411; DOI: 10.26508/lsa.202201411

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