Table of Contents
Research Articles
Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myelomaThis study defines ectopic mitochondrial chaperonin 60 (CH60) on the multiple myeloma cell surface as a HAPLN1 matrikine receptor that signals via TLR4 to induce NF-κB signaling and drug resistance.
Convergent evolution and horizontal gene transfer in Arctic Ocean microalgaeThe Arctic Ocean stands apart from other oceans. Using multiple genomes and transcriptomes from cultured and environmental sources, we found distinct genetic modifications in Arctic microalgae consistent with biogeographically constrained trait selectivity as an adaptive force in algal evolution.
Tyrosine phosphorylation controlled poly(A) polymerase I activity regulates general stress response in bacteriaWe show a tyrosine phosphorylation–controlled poly(A) polymerase I polyadenylation activity regulated stress response mechanism in bacteria that is distinct and operates downstream of the primary stress regulator RpoS.
Integrin ligands block mechanical signal transduction in baroreceptorsThe binding of integrins to specific sequences in extracellular matrix forms the mechanical coupling to transfer stretch applied on the vascular wall to the baroreceptors.
Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout ratsTSPAN7 knockout causes ASD-like phenotypes in rats through the integrin β1/FAK/SRC signal pathway, which provides novel insights into the role of TSPAN7 in psychiatric diseases, highlighting SRC as a potential target.
Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTPA mechanism that contributes to species-specific alternative splicing leading to increased coding capacity of primate genomes is presented and functionality for CamK2β splicing addressed.
An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formationThe brain-specific isoform of the GTPase Cdc42 is shown to promote axon formation by interacting with the exocyst tethering complex and increasing exocytosis downstream of its activator Arhgef7.
Loss of surface transport is a main cellular pathomechanism of CRB2 variants causing podocytopathiesCRB2 is an essential protein of the renal filtration barrier. This study reports the development of an in vitro assay, suitable to investigate the pathogenic potential of known and novel, so far uncharacterized CRB2 variants.
Unconventional interactions of the TRPV4 ion channel with beta-adrenergic receptor ligandsThe transient receptor potential vanilloid (TRPV4) ion channel is important for respiratory function. Here, it is shown that TRPV4 is inhibited by bronchodilators widely used in diseases such as asthma.
De novo discovery of traits co-occurring with chronic obstructive pulmonary diseaseThis paper integrates different levels of biological information to identify shared genetic and biological pathways underlying the diverse clinical presentations of COPD. Thus, it identifies a collection of genetic variants and genes that may aid COPD patient stratification and treatment.
Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing lossMutation-agnostic RNA interference with concomitant, knockdown-resistant gene replacement, results in robust auditory brainstem response and cochlear hair cell preservation in the murine model of TMC1-related autosomal dominant hearing loss.
Kindlin2 enables EphB/ephrinB bi-directional signaling to support vascular developmentKindlin2 supports EphB4/ephrinB2 bi-directional signaling functions by associating with a highly conserved NIYY motif in the ephrinB2 cytoplasmic tail to promote ephrinB2 clustering and EphB4 activation, thereby enabling arteriovenous segregation during embryonic development.
Trans-differentiation of trophoblast stem cells: implications in placental biologyFormation of trophendothelial cells is associated with trophoblast differentiation and is regulated by HES1. Trophoblast differentiation–induced TRAIL secretion directs preferential demise of ECs located in their vicinity, aiding trophoblast vasculogenic mimicry.
Regulation of telomere silencing by the core histones–autophagy–Sir2 axisThis work reported that there is a global loss of core histones and progressively reduced telomere silencing during yeast chronological aging and uncovered the core histones-autophagy-Sir2 pathway that contributes to the aging-coupled loss of telomere silencing.
A SNX1–SNX2–VAPB partnership regulates endosomal membrane rewiring in response to nutritional stressA specific SNX1-dependent endosome tubulation towards autophagosome biogenesis-associated regions of the ER is generated by nutrient deprivation and regulated by the SNX2/VAPB tethering complex.
PACSIN2 as a modulator of autophagy and mercaptopurine cytotoxicity: mechanisms in lymphoid and intestinal cellsThis study evaluates the role of PACSIN2 in autophagy modulation and its impact on mercaptopurine cytotoxicity in lymphoid and intestinal models.
Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely specified among human cellsPlasticity in the position of CENP-A enrichment and location of kinetochore recruitment between human cell lines is accompanied by precise CENP-A maintenance across the cell cycle to preserve unique epigenetic centromere identities among human cells.
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensingDifferential mutants confirmed Noc3’s separate roles in DNA replication and ribosome biogenesis, and an essential Noc3 dimerization cycle was found to mediate ORC dimerization in replication licensing.
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axisSMN contributes to muscle maturation by binding to the promoter regions of MYOD1 and miRNAs and regulating the expression of these molecules during myogenesis.
Lineage tracing reveals fate bias and transcriptional memory in human B cellsWe combined lineage tracing and single-cell transcriptomics to quantify the extent of cell-intrinsic fate bias in human B cells.
Secondary findings in a large Pakistani cohort tested with whole genome sequencingTesting a large Pakistani cohort with whole genome sequencing, we concluded that in countries such as Pakistan, the list of ACMG secondary findings could be expanded.
Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscleReplacement of amino acids unique to GDF11 and GDF8 into the native locus of the other ligand yields measurable, differential skeletal and muscle phenotypes, revealing distinct features between the ligands and a requirement for GDF11 in early-stage skeletal development.
Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndromeSALL4 recognises AT-rich DNA motifs via a pair of evolutionarily conserved zinc fingers, and mutations of residues critical for DNA binding are responsible for a rare developmental disorder.
An unconventional cancer-promoting function of methamphetamine in hepatocellular carcinomaMETH use is associated with a higher incidence of hepatocellular carcinoma (HCC) in METH abusers and rehabilitees. METH exposure promotes HCC progression by ROS-mediated activation of the Ras/MEK/ERK signaling pathway. Clearance of ROS by NAC abolishes METH-induced HCC progression.
Resources
IARA: a complete and curated atlas of the biogenesis of spliceosome machinery during RNA splicingThe online atlas IARA is a curated and updated resource with genetic and molecular data on the biogenesis of human spliceosome machinery involved in RNA splicing.
Disease- and sex-specific differences in patients with heart valve disease: a proteome studyProteomics provide novel insights into molecular mechanisms and cardiac remodeling in heart failure because of pressure overload in aortic valve stenosis and volume overload in mitral valve regurgitation.
