Correction: Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease

Article: Pinals RL, Tsai L-H (2022 Sep 27) Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease. Life Sci Alliance 5(11): e202201542. doi: 10.26508/lsa.202201542. PMID: 36167428.

In the initially published version of this article, a section in the Introduction reads:

In the amyloidogenic pathway, β-secretase first cleaves APP at the ectodomain, followed by γ-secretase at the intramembrane site, liberating the longer Aß-42 species. This contrasts with the physiologically normal pathway in which α- then γ-secretases consecutively cleave APP, shedding the shorter Aß-40 species.

This section should instead read:

In the amyloidogenic pathway, β-secretase first cleaves APP at the ectodomain, followed by γ-secretase at the intramembrane site, liberating Aß peptides including Aß-40 and Aß-42 (among other peptide lengths).

• Received November 22, 2022.
• Accepted November 23, 2022.

• © 2022 Pinals and Tsai

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This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).